Automatic Machine Learning Classification of Alzheimer's Disease Based on Selected Slices from 3D Magnetic Resonance Imagining
International Journal of Biomedical Science and Engineering
Volume 4, Issue 6, December 2016, Pages: 50-54
Received: Oct. 31, 2016; Accepted: Dec. 26, 2016; Published: Feb. 15, 2017
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Abdalla R. Gad, Electronic and Communication Department, Faculty of Engineering, October High Institute for Engineering and Technology, Giza, Egypt
N. M. Hussein Hassan, Electronic and Communication Department, Faculty of Engineering, Fayoum University, Fayoum, Egypt
Rania A. Abul Seoud, Electronic and Communication Department, Faculty of Engineering, Fayoum University, Fayoum, Egypt
Tamer M. Nassef, Computer and Software Department, Faculty of Engineering, Misr University for Science and Technology, Giza, Egypt
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The most dominant form of dementia, memory loss, is Alzheimer's disease (AD). Imaging is important for monitoring, diagnosis, and education of Alzheimer's disease prediction. Automated classification of subjects could provide support for clinicians. This study examined two classification methods to separate among elderly persons with normal cognitive (NC), Alzheimer's disease (AD), and mild cognitive impairment (MCI) by using images from the magnetic resonance imaging (MRI). The dataset consists of 120 subjects separated into 40 ADs, 40 MCIs, and 40 NCs. The first technique was K-Nearest Neighbor (KNN) and the second technique was Support Vector Machine (SVM), firstly all the subjects were filtered and normalized, secondly twelve features were extracted. After feature selection, two techniques of classification were examined with Permutations and combinations for all features in order to select the best features which have the highest accuracy for identification the classes. The best average accuracy was 97.92% using SVM polynomial order three, and best all average accuracy was 95.833% using KNN with K=6, and K=7 for random selection of testing data with SVM and KNN. The results show a relatively high classification accuracy between the three clinical categories. In summary, the proposed automatic classification technique can be used as a noninvasive diagnostic tool for Alzheimer's disease, with the capability of defining early stages of the disease.
Alzheimer's Disease, Magnetic Resonance Imaging, Feature Extraction, Classification, Support Vector Machine, K-nearest Neighbor
To cite this article
Abdalla R. Gad, N. M. Hussein Hassan, Rania A. Abul Seoud, Tamer M. Nassef, Automatic Machine Learning Classification of Alzheimer's Disease Based on Selected Slices from 3D Magnetic Resonance Imagining, International Journal of Biomedical Science and Engineering. Vol. 4, No. 6, 2016, pp. 50-54. doi: 10.11648/j.ijbse.20160406.11
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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