Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
American Journal of Clinical and Experimental Medicine
Volume 5, Issue 2, March 2017, Pages: 30-35
Received: Jan. 25, 2017; Accepted: Feb. 10, 2017; Published: Mar. 1, 2017
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Authors
Muhlis Yunus, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Farida Tabri, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi, Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Johanes Widodo, Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia
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Abstract
Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
Keywords
Acne Vulgaris, Autologous Serum, Doxycycline, Estradiol
To cite this article
Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, Johanes Widodo, Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris, American Journal of Clinical and Experimental Medicine. Vol. 5, No. 2, 2017, pp. 30-35. doi: 10.11648/j.ajcem.20170502.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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