Effect of Amlodipine Alone and in Combination with Enalapril on Lipid Profile in Hypertensive Patients with Chronic Kidney Disease (Gaza Strip)
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 5, September 2016, Pages: 146-150
Received: Aug. 23, 2016; Accepted: Sep. 3, 2016; Published: Oct. 11, 2016
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Hidaya Sobhi Saker, General Administration of Pharmacy, Ministry of Health, Gaza, Palestine
Amin Tawfeeq Hamed, Collage of pharmacy, Alazhar University, Gaza, Palestine
Amal Fares Jamee, Al Shifa Hospital, Cardiology Department, Ministry of Health, Gaza, Palestine.
Mahmoud Jalal Wadi, Nasser Medical Complex, Kidney and Dialysis Department, Ministry of Health, Gaza, Palestine
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Hypertension with dyslipidemia is becoming a common morbidity and hyperlipidemia is considered as an independent risk factor in development of cardiovascular diseases [1]. To evaluate the effects of Amlodipine (Calcium channel blocker) alone and in combination with Enalapril (Angiotensin Converting Enzyme inhibitor) on serum lipid profile in hypertensive patients with Chronic Kidney Disease (CKD), fifty hypertensive patients with CKD were divided equally into Amlodipine (5-10mg/day) treated group and Amlodipine/Enalapril combination (5-10mg/day, 10-20mg/day) treated group. Serum lipid profile were determined before and after 2, 4 and 6 months of treatment in both groups. A significant decrease in the levels of serum lipid profile in the hypertensive patients with CKD resulted with Amlodipine therapy alone and in combination with Enalapril. In both treated groups, the used drugs significantly improved Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels of the patients. The effect on these parameters being more pronounced in the group treated with the combination drug, when compared to that of Amlodipine treatment alone. The results indicated that both, Amlodipine monotherapy as well as Amlodipine/Enalapril combination affect the lipid profile. The observed overall higher protective effect of the combination as compared to that of Amlodipine monotherapy may improve the cardiovascular changes caused by hypertensive nephropathy.
Chronic Kidney Disease, Serum Lipid Profile, Hypertension, Amlodipine, Amlodipine/Enalapril Combination
To cite this article
Hidaya Sobhi Saker, Amin Tawfeeq Hamed, Amal Fares Jamee, Mahmoud Jalal Wadi, Effect of Amlodipine Alone and in Combination with Enalapril on Lipid Profile in Hypertensive Patients with Chronic Kidney Disease (Gaza Strip), American Journal of Clinical and Experimental Medicine. Vol. 4, No. 5, 2016, pp. 146-150. doi: 10.11648/j.ajcem.20160405.16
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