The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 3, May 2016, Pages: 68-75
Received: Apr. 21, 2016;
Accepted: May 3, 2016;
Published: May 13, 2016
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Fadlina Zainuddin, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Khairuddin Djawad, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Arifin Seweng, Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Rizalinda Sjahril, Department of Microbiology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anni Adriani, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.
Anis Irawan Anwar,
The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar, American Journal of Clinical and Experimental Medicine.
Vol. 4, No. 3,
2016, pp. 68-75.
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