Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 3, May 2015, Pages: 124-127
Received: Apr. 23, 2015;
Accepted: May 6, 2015;
Published: May 21, 2015
Views 3937 Downloads 88
Yulianty Mochtar, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Nadirah Rasyid Ridha, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Dasril Daud, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Follow on us
Introduction: Relapse in children with leukemia is a phase appearing the leukemia cells after complete remission; this situation can impact the children itself, parents and also the support system. Objective: To identify the factors related of relapse incidence in children with leukemia. Methods: This study was conducted by using a retrospective cohort study design based on medical record data from Dr. Wahidin Sudirohusodo Hospital, Makassar from December 2013 until August 2014. Study samples were children of 0 month – 18 years old diagnosed of having Acute Lymphoblastic Leukemia-L1. They are treated with chemotherapy and divided into relapse and non-relapse samples. Results: From 42 relapse and non-relapse samples, there were 35.7% (15) relapse samples and 64.3% (27) non relapse samples. Bivariate analyses revealed that among 1-10 year, there were 31.4% (11) with relapse and 68.6% (24) without relapse. Among the samples aged more than 10 years old, there were 57.1% (4) samples with relapse and 42.9% (3) samples without relapse, with p=0.225 (p>0.05). In terms of interval time from first diagnosis until the occurrence of relapse, the median value was 1.80 in 1-10 year-old group. In the group of >10 years old, the median value was 0.84 and p=0.207 (p>0.05). Conclusion: Age did not give any influence in the incidence of relapse in children with ALL-L1 and the interval time when the first diagnosed until relapse.
Acute Lymphoblastic Leukemia-L1, Relapse, Age, Children
To cite this article
Nadirah Rasyid Ridha,
Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children, American Journal of Clinical and Experimental Medicine.
Vol. 3, No. 3,
2015, pp. 124-127.
Pui CH, Evans. Acute lymphoblastic leukemia. Eng J Med. 2004; 339: 605-15.
Cancer Council. Statistics Leukemia. Updated March 2009 based on latest data (2006). 2009.
Mostert, Saskia., Sitaresmi M.N., Gundy C.M., Sutaryo., Veerman A.J. Influence of socioeconomic status on childhood acute lymphoblastic leukemia treatment in Indonesia. Pediatrics. 2006; 118e:1600-1606.
Silverman L.B., Sallan S.E. Acute lymphoblastic leukemia. Hematology of infancy and children. Saunder. 2003; 6: 1135-66.
Margolin J.R., Stember C.P., Poplack D.G. Principles and practice of pediatric oncology. Philadelpia. 2002; 489-544.
Rubnitz J.E., Crist W.M. Molecular genetics of childhood cancer: Implications for pathogenesis, diagnosis, and treatments. Pediatrics. 1997; 100: 101-08.
Silverman L.B. Childhood acute lymphoblastic leukemia: Currently applied prognostic factors. International Society of Paediatric oncology. 2000.
Beutler, Ernest, et al., 2000. Williams Hematology 6th edition. New York: McGraw-Hill Professional.
Hoffman, R., Benz, E. J., Shattil, S. J., Furie, B., Cohen, H. J., Silberstein, L. E., et al. (Eds.). Hematology: basic principles and practice, 3rd edition. New York: Churchill Livingstone. 2000.
Plasschaert L.S., Kamps W.A., Velengga E. Prognosis in childhood acute lymphoblastic leukemia: A question of maturation. Cancer Treat Rev. 2004; 30: 37-51.
Niemeyer C.M., Sallan S.E. Acute lymphoblastic leukemia. In: Nathan DG, Orkin SH. Hematology of Childhood and Infancy. Philadelphia. Saunders. 1998; 5
Widiaskara dkk., Outcomes phase induction treatment of acute lymphoblastic leukemia in children at Dr. Soetomo hospital. Sari Pediatri. 2010; 12 (2).
Mulatsih S., Silvia M. Acute lymphoblastic leukemia in children age under one year old. Sari Pediatri. 2009; 3 (4): 102-07.
Pui C.H., Boyett J.M., Rivera G.K. Long term results of total therapy studies 11, 12 and 13 A for childhood acute lymphoblastic leukemia at St Jude Children’s Research Hospital. Leukemia. 2000; 14: 2286-294.
Meidiana B. Factor analyses of genesis relapse in children with leukemia. Jakarta: RS Cipto Mangunkusomo. 2012.
Permono B., Sutaryo., Ugrasena I.D.G., Windiastuti E. Acute leukemia in Hematology-Oncology of Child Textbook. Jakarta: Publisher Agency of Indonesian Pediatric Association. 2006; 2.