The Relationship of Salivary Free Testosterone Concentration with Acne Vulgaris
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 2, March 2015, Pages: 73-77
Received: Mar. 22, 2015; Accepted: Apr. 1, 2015; Published: Apr. 10, 2015
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Authors
Andi Fausiah Abdullah, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Anis Irawan Anwar, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Faridha Ilyas, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Sri Vitayani Muchtar, Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Burhanuddin Bahar, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Andi Makbul Aman, Department of Internal Medicine, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
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Abstract
Background: Acne Vulgaris (AV) is a chronic inflammatory and multifactorial disease involving the pilosebaceous unit. Androgen hormone plays an important role in the pathogenesis of acne. Objective: This study aims to determine the relationship of free testosterone concentration with the severity of acne vulgaris. Methods: This is an observational study using cross sectional design. This study conducted in Dr. Wahidin Sudirohusodo hospital, Hasanuddin University hospital, and other hospital networks and Prodia laboratory in Makassar starting from January until February 2015. The study samples are 42 patients who met the study criteria. There are 32 patients with AV who have been diagnosed clinically and 10 patients with non AV as a control group. Results: The free testosterone concentration and sebum levels in the AV group are higher compared to the control group (p<0.005). This study obtained that there is no significant difference of free testosterone concentration and sebum levels according to the AV levels (p>0.005), but there is a correlation between the free testosterone concentration with the increased of sebum levels. It is mean that even the free testosterone concentration and sebum levels are increased, the acne vulgaris is not necessarily severe, but the increased of free testosterone concentration makes the sebum levels increased. Conclusions: The free testosterone concentration and sebum levels are higher in the acne vulgaris group than the control group. There is no significant relationship of free testosterone concentration with acne vulgaris with p>0.05.
Keywords
Free Testosterone, Sebum Levels, Acne Vulgaris
To cite this article
Andi Fausiah Abdullah, Anis Irawan Anwar, Faridha Ilyas, Sri Vitayani Muchtar, Burhanuddin Bahar, Andi Makbul Aman, The Relationship of Salivary Free Testosterone Concentration with Acne Vulgaris, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 2, 2015, pp. 73-77. doi: 10.11648/j.ajcem.20150302.15
References
[1]
Zaenglein A, Graber E, Thiboutot D, Strauss J. Acne Vulgaris and Acneiform Eruptions. In: Wolff K, Goldsmith L, Katz S, editors. Fizpatrick's Dermatology in General Medicine. 7 ed. Mc Graw Hill 2008.
[2]
Zouboulis C. Acne as a chronic systemic disease. Clinics in Dermatology. 2014;32:389-96.
[3]
Simpson N, Cunliffe W. Rook's textbook of dermatology. Massachusetts: Blackwell Science; 2007.
[4]
Dreno B, Poli F. Epidemiology of Acne. Dermatology. 2003;206:76-10.
[5]
Lehmann H, Andrews J, Holloway V, Goodman S. Acne therapy: a methodologic review. J Am Acad Dermatol. 2002;47:231-40.
[6]
Thiboutot D, Gilliland K, Light J, Lookingbill D. Androgen Metabolism in Sebaceous Glands From Subjects With and Without Acne. Arch Dermatol. 1999;135:1041-5.
[7]
Sharp L, Cardy AH, Cotton SC, Little J. CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors. Am J Epidemiol. 2004;160:729-40.
[8]
Lawrence D, Shaw M, Kats M. Elevated free testosterone in men and women with acne vulgaris. Clinical and Experimental Dermatology. 1986;II:263-73.
[9]
Cunha Md, Macedo M, Fonseca FL, Filho C. The importance of the evaluation of androgen levels in adult women with acne: Brazilian casuistic report. OA Dermatology. 2013;1(1):1-5.
[10]
F.Ballanger, P.Baudry, J.M.N'Guyen, A.Khammari, B.Dreno. heredity:A Prognostic Factor for Acne. Dermatology. 2006;212:145-9.
[11]
Leyden J. Topical treatment of acne vulgaris: retinoid and cutaneous irritation. J Am Acad Dermatol. 1998;38:S1-4.
[12]
Gollnick H, Cunliffe W. Management of Acne. J Am Acad Dermatol. 2003;41:S1-38.
[13]
Baumann M. Cosmetic dermatology principles and practice. New York: The McGraw-Hill Companies; 2002.
[14]
Mustikawati E, Anwar AI, Amin S, massi N, Bur B. Hubungan polimorfisme gen cyp17 dan peningkatan kadar sebum pada akne vulgaris. Makassar: Hasanuddin University.; 2011.
[15]
Lolis MS, Bowe WP, Shalita AR. Acne and Systemic Disease. Med Clin N Am. 2009;93:1161-81.
[16]
Baumann L, Keri J. Cosmetic Dermatology. New York: McGraw-Hill.; 2009.
[17]
Rivera R, Guerra A. Management of Acne in Women Over 25 Years of Age. Actas Dermosifiliogr. 2009;100:33-7.
[18]
Addor FASS, Schalka S. Acne in adult women : epidemiological, diagnostic and therapeutic aspects. . An Bras Dermatol. 2010;85:789-95.
[19]
Sulaiman AA. The Influence of hormones on acne in females. Middle east journal of family medicine. 2013;11:6-9.
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