Oil Machinery Fluid of Craniopharyngioma. Biochemical Analysis: Clinico-Pathological Correlation
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 2, March 2015, Pages: 52-58
Received: Dec. 16, 2014; Accepted: Jan. 26, 2015; Published: Feb. 16, 2015
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Martha Lilia Tena Suck, Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Cuidad de México, México, Av. Insurgentes sur no 3788, Colonia la Joya, delegación Tlalpan, México D. F. Cp. 14269, y Escuela Superior de Medicina, Estudios de Post-grado, Instituto Politécnico Nacional, Ciudad de México; Escuela Superior de Medicina, Estudios de Post-grado, Instituto Politécnico Nacional, Ciudad de México
Andrea Y. Morales del Ángel, Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía, Cuidad de México, México
Ma. Elena Hernández-Campos, Escuela Superior de Medicina, Estudios de Post-grado, Instituto Politécnico Nacional, Ciudad de México
Manuel Castillejos-López, Departamento de Epidermiología Clínica, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México
Georgina González-Ávila, Laboratorio de Oncología biomédica, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México
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Craniopharyngiomas are histologically benign tumors, but they have a tendency to become adherent around the pituitary gland and pituitary stalk, including the optic nerves, optic chiasm, intracranial arteries and the brain itself. 15 cases of craniopharyngiomas were included in this study. The oil fluid biochemical analysis was made; glucose, cholesterol, lipids, proteins, lactate dehydrogenase, globulins, calcium, sodium, etc. and Western Blot was performed for 2 and 9 metalloproteins. Clinicopatological correlation was made. Groups were divided in recurrent and non-recurrent tumor. The age of patient ranged from 18 to 51 yr 11 (mean of 30yrs). 11 (73%) were females and 4 (27%) were male. Recurrence was in 8 (53%) cases. We analyze the mean of laboratory results obtaining normal to low serum values for ions and high fluid values for all the elements studied. There was no statically significance between them, but we observe the patients which had a big tumor, recurrence and green color oil fluid presented high levels of these components. By the other hand, little not recurrent tumors and with a yellow oil fluid aspect, had low serum values of alkaline phosphatase, serum glutamic oxaloacetic and glutamic-pyruvic transaminases. The output of these components in the Central Nervous System can be toxic and produce more inflammatory response.
Craniopharyngioma, Oil Fluid, Oil Machinery, Oil Content, 2 and 9 Metalloproteinase
To cite this article
Martha Lilia Tena Suck, Andrea Y. Morales del Ángel, Ma. Elena Hernández-Campos, Manuel Castillejos-López, Georgina González-Ávila, Oil Machinery Fluid of Craniopharyngioma. Biochemical Analysis: Clinico-Pathological Correlation, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 2, 2015, pp. 52-58. doi: 10.11648/j.ajcem.20150302.11
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. The 2007 WHO Classification of Tumours of the Central Nervous System. ActaNeuropathol (Berl) 2007; 114:97-109.
Sekine S, Takata T, Shibata T, et al. "Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation". Histopathology 2004; 45 (6): 573–9.
Müller H. L. Consequences after craniopharyngioma surgery in children. J. Clin. Endocrinol. Metab. 2011; 96, 1981–1991
Müller H. L., Albanese A., Calaminus G., Hargrave D., Garré M. L., Gebhardt U., Saran F., Sörensen N., Spoudeas H. A. Consensus and perspectives on treatment strategies in childhood craniopharyngioma – results of a meeting of the craniopharyngioma study group (SIOP), Genova 2004. J. Pediatr. Endocrinol. Metab. 2006a; 19, 453–454
Hamid R, Sarkar S, Hossain MA, Mazumder U, Akanda NI, Parvin R "Clinical picture of craniopharyngioma in childhood". Mymensingh medical journal. 2007; 16: 123-6.
Ahmet A, Blaser S, Stephens D, Guger S, Rutkas JT, Hamilton J. Weight gain in craniopharyngioma; a model for hypothalamic obesity. J PediatrEndocrinolMetab. 2006;19:121-127.
Ikeda H, Yoshimoto T. Clinicopathological study of Rathke's cleft cysts. . ClinNeuropathol. 2002; 21: 82-91.
Gutierrez LP, Koltowska-Haggstrom M, Jonsson PJ, Mattsson AF, Svensson D, Westberg B & Luger A. Registries as a tool in evidence-based medicine: example of KIMS (Pfizer International Metabolic Database). Pharmacoepidemiology and Drug Safety 2008 17 90–102.
Chatterjee S, Kesavadas C, Menon G, Nair S, Radhakrishnan VV. Changing signal intensity of a craniopharyngioma. Neurol India. 2010; 58:468-70.
Hayashi Y, Tachibana O, Muramatsu N, Tsuchiya H, Tada M, Arakawa Y, Suzuki M, Yamashita J. Rathke cleft cyst: MR and biomedical analysis of cyst content. . J Comput Assist Tomogr. 1999; 23:34-38.
Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, boeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid Anal Biochem 1985; 150:76-85.
Vadillo-Ortega F, González-Avila G, Furth EE, Lei H, Muschel RJ, Stetler-Stevenson WG, Strauss III JF. 92-kd Type IV collagenase (matrix metalloproteinase-9) activity in human amniocorion increases with labor. Am J Pathol 1995; 146:148-156.
Arefyeva IA, Semenova JB, Zubairaev MS, Kondrasheva EA, Moshkin AV. Analysis of fluid in craniopharyngioma-related cysts in children: proteins, lactate and pH.ActaNeurochir (Wien). 2002; 144:551-54.
Hama S, Arita K, Nishisaka T, Fukuhara T, Tominaga A, Sugiyama K, Yoshioka H, Eguchi K, Sumida M, Heike Y, Kurisu K. Changes in the epithelium of Rathke cleft cyst associated with inflammation. J Neurosurg. 2002; 96:209-16.
Szeifert GT, Julow J, Szabolcs M, Slowik F, Bálint K, Pásztor E. Secretory component of cystic craniopharyngiomas: a mucino-histochemical and electron-microscopic study. Surg Neurol. 1991; 36: 286-93.
Martelli C, Iavarone F, Vincenzoni F, Rossetti DV, D'Angelo L, Tamburrini G, Caldarelli M, Di Rocco C, Messana I, Castagnola M, Desiderio C. Proteomic characterization of pediatric craniopharyngioma intracystic fluid by LC-MS integrated approaches. Electrophoresis. 2014; 35:2172-83.
Desiderio C, Martelli C, Rossetti DV, Di Rocco C, D'Angelo L, Caldarelli M, Tamburrini G, Iavarone F, Castagnola M, Messana I, Cabras T, Faa G. Identification of thymosins β4 and β 10 in paediatri craniopharyngioma cystic fluid. Childs Nerv Syst. 2013; 29: 951-60.
Yokoyama S, Goto M, Hirano H, Hirakawa W, Noguchi S, Hirahara K, Kadota K, Asakura T. Pituitary Adenoma with Cholesterol Clefts. EndocrPathol. 1998; 9:91-95.
Rajput D, Srivastva A, Kumar R, Mahapatra A. Recurrent chemical meningitis in craniopharyngioma without reduction in size of cyst: case report of two cases and review of the literature. Turk Neurosurg. 2012; 22: 233-6.
Fischer B, Palkovic S, Schildheuer D, Heindel W, Wassmann H. Inflammatory thromboembolic complication after craniopharyngioma surgery? ActaNeurochir (Wien). 2004; 146:183-6.
Aref'eva IA, SemenovaZhB, Korshunov AG, Zubaĭraev MS, Krasnova TS, Gorelyshev SK, PromyslovMSh. Lipid peroxidation in the cyst fluid of craniopharyngiomas. Vopr Med Khim. 2001; 47:625-32.
Müller HL, Gebhardt U, Schröder S, Pohl F, Kortmann R D, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sörensen N. Analyses of treatment variables for patients with childhood craniopharyngioma – results of the multicenter prospective study trial KRANIOPHARYNGEOM 2000 after three years of follow up. Horm. Res. Paediatr; 2010; 73: 175-180.
Müller H. L., Faldum A., Etavard-Gorris N., Gebhardt U., Oeverink R., Kolb R., Sörensen N. Functional capacity, obesity and hypothalamic involvement crosssectional study on 212 patients with childhood craniopharyngioma. Klin. Padiatr 2003a; 215: 310-314.
DeVile CJ, Grant DB, Hayward RD, Stanhope R. Growth and endocrine sequelae of craniopharyngioma. Arch. Dis. Child. 1996a; 75: 108-114
Puget S, Garnett M, Wray A, Grill J, Habrand JL, Bodaert N, Zerah M, Bezerra M, Renier D, Pierre-Kahn A, Sainte-Rose C. Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. J Neurosurg 2007; 106, 3-12.
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