Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia
American Journal of Clinical and Experimental Medicine
Volume 2, Issue 6, November 2014, Pages: 128-131
Received: Oct. 10, 2014;
Accepted: Nov. 6, 2014;
Published: Nov. 20, 2014
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Salil Vaniawala, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza-A , Near RTO circle, Surat-395001, India
Gadhia Pankaj, P. K. Gadhia, Molecular Cytogenetic Unit, S. N. Gene Lab. and Research Centre, Near RTO circle, Surat – 395001. India
In the present study, we screened the bone marrow chromosome database entries between March, 2004 and December, 2013 to identify cases with inv(9) along with t(9;22) variations. Our study recorded 2300 cases of confirmed CML (Ph positive), of which only 12 (0.52%) cases had inv(9) and t(9;22). The association between inv(9) and t(9;22) is not fully explored. Therefore more number of cases is required to shed light on its important role, if any, especially in bone-marrow transplantation and drug resistance.
Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia, American Journal of Clinical and Experimental Medicine.
Vol. 2, No. 6,
2014, pp. 128-131.
T. M. Ko, F. J. Hsieh, L. S. Chang, M. F Pan, and T. Y Ley. “Pericentric inversion of chromosome 9 in Taiwanese foetuses”. J Formos Med Asso vol. 91, pp. 473-474, 1992.
S. Uehara, Y. Akai, Y. Takeyama, T. Takabayashi, K. Okumura, and A. Yajima. “Pericentric inversion of chromosome 9 in prenatal diagnosis and infertility”. Tohoku J Exp. Med. vol.166, pp. 417-427. 1992.
S. Daya. “Issue in etiology of recurrent spontaneous abortion”. Curr Opin Obst Gynecol. vol. 6, pp.153-159, 1994.
Y. Inayama, H. Yoneda, K. Fukushima, J. Sakai, H. Asba, and .T Skai. “Pericentric inversion of chromosome 9 with schizoaffective disorder”. Clin genet. vol.51, pp. 69-70, 1997.
C. Milan, and L.Laberti. “Study of C-polymorphism of chromosome 1,9,16 in lymphocytes of patients with laryngeal carcinoma”. Boll Soc. Ital Biol Sper. vol. 72, pp.187-194, carcinoma”. Boll.Soc.Ital. Biol. Sper. Vol.72, pp.187-194,1996.
T. Yasuhara, A. Okamoto , T. Kitagwa, T. Nikaido, T. Yoshimura, T. Vanaihara, S. Takakura, T. Tanaka, K. Ochiai and Y. Ohtake. “FGF7 like gene associated with pericentric inversion of chromosome 9 and FGF7 is involved in the development of ovarian cancer”. Int J Oncol. vol.26, pp. 1209 – 1216, 2005.
M. A. Seabright. “A rapid banding technique for human chromosome”. Lancet. Vol. 2,pp. 971-972, 1971
International System for Human Cytogenetics Nomenclature (ISCN), S. Karger Pbl. Inc. (2009).
S.G.Lee, T.S.Park, G. Lim, K.A.Lee, J. Song and J.R.Choi. “Constitutional pericentric inversion and hematological disorders. A Korean tertiary Institution experience over eight years. Vol.40, pp.273-277, 2010.
M. L.Coniar,. D. Veccchione, . A. Bernheim, and R. Berger. “C-banding studies in acute nonlymphocytic leukemia”. Can. Genet. Cytogent. Vol. 5, pp.327-331, 1982.
I. Petkovic, M. Nakic, J. Konja. “Heteromorphic varability in children with acute lymphocytic leukemia”. Can. Genet. Cytogenet. Vol. 54. Pp.67-69, 1991.
T. S. Wan, S.K. Ma, and I.C.Chan. “Acquired pericentric inversion of chromosome 9 in essential thrombocytopenia”. Humn. Genet. Vol. 106, pp.669-670, 2000.
Y.K.Keung, M.A. Knovich, B>L.Powell, D.H. Buss and M. Pettenanti. “Constitutional pericentric inversion of chromosome 9 and acute leukemia. Can. Genet. Cytogen. Vol.145, pp.82-85, 2003
B. Suh, J. Song, J. Kim, T.S. Park and J. R. Choi. “Constitutional pericentric inversion 9 in Korean patients with chronic myelo- genous leukemia”. Kor.J. Lab. Med. Vol.30, pp. 218-223, 2010.