Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis with Pulmonary Tuberculosis
American Journal of Internal Medicine
Volume 6, Issue 5, September 2018, Pages: 94-98
Received: Jun. 27, 2018;
Accepted: Jul. 23, 2018;
Published: Aug. 24, 2018
Views 1447 Downloads 119
Arti Sharma, Department of Pulmonary Medicine, D. Y. Patil Medical College, Navi Mumbai, India
Abhay Uppe, Department of Pulmonary Medicine, D. Y. Patil Medical College, Navi Mumbai, India
Shahid Patel, Department of Pulmonary Medicine, D. Y. Patil Medical College, Navi Mumbai, India
Girija Nair, Department of Pulmonary Medicine, D. Y. Patil Medical College, Navi Mumbai, India
Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disease, characterised by widespread intra-alveolar accumulation of microliths. A 30-year-old male patient, known case of rheumatioid arthritis on treatment, presented with occasional complaints of cough with expectoration, since 1 year. He was found to be sputum AFB positive for which AKT was started, and a chest xray was advised, which showed diffuse bilateral micronodular calcific opacities having sand-like appearance distributed throughout the lungs, with a evident black pleural sign, which made us suspect PAM. An HRCT chest showed, multiple dense micronodular opacities in bilateral lung parenchyma prominently in the middle and lower lung zones giving a classical sandstorm appearance with sparing of a thin peripheral subpleural rim of parenchyma, giving a black pleura sign. The patient was symptomatically treated and was counselled for lung transplant and presents for regular follow up.
Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis with Pulmonary Tuberculosis, American Journal of Internal Medicine.
Vol. 6, No. 5,
2018, pp. 94-98.
Corut A, Senyiğit A, Ugur SA, et al. Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. Am J Hum Genet 2006; 79: 650–656.
Zhang Y, Yang Y, Yu T, Qiao JH, Tumen WL, Wu CF, Ma ZS. Three cases of pulmonary alveolar microlithiasis in a family and clinical analysis]. Zhonghua Jie He He Hu Xi Za Zhi. 2008 Feb; 31 (2):112-5. Review. Chinese.
Castellana G, Gentile M, Castellana R, Fiorente P, Lamorgese V. Pulmonary alveolar microlithiasis: clinical features, evolution of the phenotype, and review of the literature. Am J Med Genet. 2002 Aug 1; 111 (2):220-4. Review. PMID: 12210357.
Izumi S, Miyazawa H, et al. Huqun, Izumi S, Miyazawa H, etal. Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med 2007; 175: 263–268.
Ferreira Francisco FA, Pereira e Silva JL, Hochhegger B, et al. Pulmonary alveolar microlithiasis. State-of-the-art review. Respir Med 2013; 107: 1–9.
Al-Sardar H, Al-Habbo DJ, Al-Hayali RM Pulmonary alveolar microlithiasis: report of two brothers with the same illness and review of literature. BMJ Case Rep. 2014 Mar 31; 2014. pii: bcr2013201300. doi: 10.1136/bcr-2013-201300. Review. PMID: 24686795.
La casistica della Puglia. Rass Pat App Respir Microlitiasi alveolare polmonare: proposta di iter diagnostico ottimale 2004; 19: 323–328. Castellana G.
Castellana G, Lamorgese V, Lombardi P, et al. Microlitiasi alveolare polmonare: proposta di iter diagnostico ottimale. La casistica della Puglia. Rass Pat App Respir 2004; 19: 323–328.
Yin X, Wang H, Wu D, et al. SLC34A2 gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures. Respir Med 2013; 107: 217–222
Castellana G. Lamorgese V. Pulmonary Alveolar Microlithiasis Respiration 2003; 70:549–555.
Khaladkar SM, Kondapavuluri SK, Kamal A, Kalra R, Kuber R Pulmonary Alveolar Microlithiasis - Clinico-Radiological dissociation - A case report with Radiological review. J Radiol Case Rep. 2016 Jan 31; 10 (1):14-21. doi: 10.3941/jrcr.v10i1.2528. eCollection 2016 Jan. Review. PMID: 27200151.
Proesmans M, Boon M, Verbeken E, et al. Pulmonary alveolar microlithiasis: a case report and review of the literature. Eur J Pediatr 2012; 171: 1069–1072.
Yang Y, Qiao JH, An JH, et al. [Detection of SLC34A2 in patients with pulmonary alveolar microlithiasis and the effect of SLC34A2 on transportation of calcium and phosphate in human alveolar epithelial cells]. Zhonghua Jie He He Hu Xi Za Zhi 2008; 31: 908–911.
Jönsson ÅL, Simonsen U, Hilberg O, Bendstrup E Pulmonary alveolar microlithiasis: two case reports and review of the literature. Eur Respir Rev. 2012 Sep 1; 21 (125):249-56. doi: 10.1183/09059180.00009411. Review. PMID:22941890.
Ozcelik U, Yalcin E, Ariyurek M, et al. Long-term results of disodium etidronate treatment in pulmonary alveolar microlithiasis. Pediatr Pulmonol 2010; 45: 514–517.
Azim S, Azim W, Hayat F, et al. Treatment of pulmonary alveolar microlithiasis with allendronate sodium. Biomedica 2004; 20: 32–35. Stamatis G, Zerkowski HR, Doetsch N, et al. Sequential bilateral lung transplantation for pulmonary alveolar microlithiasis. Ann Thorac Surg 1993; 56: 972–975.
Edelman JD, Bavaria J, Kaiser LR, et al. Bilateral sequential lung transplantation for pulmonary alveolar microlithiasis. Chest 1997; 112: 1140–1144.
Samano MN, Waisberg DR, Canzian M, Campos SV, Pêgo-Fernandes PM, Jatene FB Lung transplantation for pulmonary alveolar microlithiasis: a case report. Clinics (Sao Paulo). 2010 Feb; 65 (2):233-6. doi: 10.1590/S1807-59322010000200016. PMID: 20186308.
Jackson KB, Modry DL, Halenar J, et al. Single lung transplantation for pulmonary alveolar microlithiasis. J Heart Lung Transplant 2001; 20: 226.
Shadmehr MB, Arab M, Pejhan S, et al. Eight years of lung transplantation: experience of the National Research Institute of Tuberculosis and Lung Diseases. Transplant Proc 2009; 41: 2887–2889.
Borrelli R, Fossi A, Volterrani L, et al. Right single-lung transplantation for pulmonary alveolar microlithiasis. Eur J Cardiothorac Surg 2014; 45: e40.
Coulibaly B, Fernandez C, Reynaud-Gaubert M, et al. Microlithiase alvéolaire avec fibrose leading to lung sévère conduisant à la greffe. Ann Pathol 2009; 29: 241–244.
Samano MN, Waisberg DR, Canzian M, et al. Lung transplantation for pulmonary alveolar microlithiasis: a case report. Clinics (Sao Paolo) 2010; 6: 233–236.
Shigemura N, Bermudez C, Hattler BG, et al. Lung transplantation for pulmonary alveolar microlithiasis. J Thorac Cardiovasc Surg 2010; 139: e50–e52.
Siddiqui NA, Fuhrman CR. Best cases from the AFIP: pulmonary alveolar microlithiasis. Radiographics 2011; 31: 585–590.
Klikovits T, Jaksch P, Hoda M, et al. A seldom indication for lung transplantation: pulmonary alveolar microlithiasis – the Vienna experience. Joint Annual Congress of the German, Austrian and Swiss Society of Thoracic Surgery, Basel, Switzerland, October 24–26, 2013.
Gusyetmez B, Ogan A, Ayyildiz AC, et al. Lung transplantation in an intensive care patient with pulmonary alveolar microlithiasis – a case report. F1000Res 2014; 3: 118.