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Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review
American Journal of Internal Medicine
Volume 5, Issue 5, September 2017, Pages: 91-94
Received: May 14, 2017; Accepted: Jun. 6, 2017; Published: Oct. 24, 2017
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Veljko Flego, Department of Pulmonology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Helmut Popper, Institute of Pathology, Medical University of Graz, Graz, Austria
Darian Volaric, Primary Health Care Office, Health Centre of Primorsko-Goranska County, Rijeka, Croatia
Ljiljana Bulat-Kardum, Department of Pulmonology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
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Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy.
Neoplasms, Histiocytic Sarcoma, Lung, Immunohistochemistry, Surgical Treatment
To cite this article
Veljko Flego, Helmut Popper, Darian Volaric, Ljiljana Bulat-Kardum, Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review, American Journal of Internal Medicine. Vol. 5, No. 5, 2017, pp. 91-94. doi: 10.11648/j.ajim.20170505.16
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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