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Diabetes Mellittus and the Risk of Cancer Formation – Possible Link and Review of Literature
American Journal of Internal Medicine
Volume 3, Issue 4, July 2015, Pages: 180-184
Received: Jun. 10, 2015; Accepted: Jul. 10, 2015; Published: Jul. 17, 2015
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Ekpe, Ekpe Lawson, Department of Chemical Pathology, University of Calabar, Calabar, Nigeria
Omotoso Ayodele Joshua, Department of Pathology, University of Calabar, Calabar, Nigeria
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Background: The incidence of cancer is increased in patients with Type 2 diabetes mellitus. The aetiology is not exactly known. Various studies have been done to ascertain this fact. Aim: The aim of this study was to access the correlation between cancer and diabetes mellitus. Method: Using internet search, a comprehensive literature review was done and words such as diabetes mellitus, cancer, breast, pancreas, colorectal, prostate, liver, were searched from google scholar, yahoo, pubmed, medline, web MD to check for various articles published on this subject. The references of the relevant articles were also searched. Results: Analyses of results of various studies were considered and their RR were noted to access the correlation between cancer and diabetes mellitus. Conclusion: There is an increased fold rise of various cancers among type 2 diabetes mellitus patients.
Cancer, Diabetes Mellitus, Breast, Liver, Prostate, Pancreas, Odds Ratio
To cite this article
Ekpe, Ekpe Lawson, Omotoso Ayodele Joshua, Diabetes Mellittus and the Risk of Cancer Formation – Possible Link and Review of Literature, American Journal of Internal Medicine. Vol. 3, No. 4, 2015, pp. 180-184. doi: 10.11648/j.ajim.20150304.15
Whiting DR, Guariguata L, Weil C, Shaw J: IDF diabetes atlas. Global estimate of the prevalence of diabetes for 2011 and 2030. Res Clin Pract. 94:311-321. 2011.
Centers for disease control and prevention. National Diabetes fact sheet. 2011.
Hermminski K, Li X, Sundquist J, Sundquist K. Risk of cancer following hospitalization for type 2 diabetes. The oncologist endocrinology 15: 548-555. 2010.
Adeghate E, Schattner P, Dunn E. an update on the etiology and epidemiology of diabetes mellitus. Ann NY acad sci. 1084: 1-29, 2006.
Hussain A, Claussen B, Ramachandran et al. Prevention of type 2 diabetes. Res Clin Pract. 76: 317-326. 2007.
Ringborg A, Lindgren P, Martinell M, et al. Prevalence and incidence of type 2 d diabetes and the complications – 1996-2003- estimates from a Swedish population based study. Diabet Med 25: 1178-1186. 2008.
Josh Sanket, Liu Morghan, Tuner Nigel. Diabetes and its link with cancer. Providing the fuel and spark to launch and aggressive growth regime. Biomed Research International. 2015.
Vigneri P, Frasca F, Sciacca L. Pandini G, Vigneri R. diabetes and cancer. Endocrine-Related Cancer 16: 1103-1123. 2009.
Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical Diabetes.26(2):77-82.2008
Smith U,Gale EM.Does Diabetes therapy influence the risk of cancer.Diabetetologia.52:1699-1708.2009s
Czyzyk Artur, Szczepanik. Zdzislacva. Diabetes mellitus and cancer 11(5) :245-252. 2000.
Chowdhury TA. Diabetes and cancer.QJM,103(12)903-915, 2010.
Huxley R, Ansary-Morghaddan A, Gonzalez A., et al. Type 2 diabetes and pancreatic cancer : A meta-analysis of 36 studies. Br J cancer 92(11): 2076-83. 2005.
Stevens RJ, Rouldam AW, Beral V. Pancreatic cancer in type 1 and young-onset diabetes. Systematic review and meta-analysis. Br J cancer 96(3): 507-509 – 2007.
Magruder JT, Anderson DK. Diabetes and pancreatic cancer: chicken or egg. Pancreas 40(3) 339-51. 2011.
Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis – JAMA. : 273(20) 24-31.
Muniraj T, Chin ST. Diabetes and Cancer.Minneaxa gastroenterol dietol. 58(4).
Giovanucci E. Insulin and colon cancer. Cancer causes control. 6:164-79, 1995
Larson SC, Orsini N, Wolk A. Diabetes mellitus and risk of colorectal cancer: A meta-analtysis. J Natl Cancer Inst. 97(22). 1679-87. 2005.
Peters PJ, Bazelier MT, Leufkens HG, Frank V, Bruon ML. The risk of colorectal cancer in patients with type 2 diabetes. Association with treatment and obesity. Diabetes care. 2014.
Hil FB, Mansin JE, Hanter D, Colditz CA, et al. Prospective study of adult onset DM (type 2) and risk of CRC in women. J Natl. Cancer Inst. 91(6). 542-2. 1999.
Larson SC, Giovanniuci E, Wolk A. Diabetes and colorectal cancer incidence in the cohort of Swedish man.
Tolman KG, Funseca V, Dalpiaz A, Tan Merg. Spectrum of liver diseases in type 2 DM and management of Patients with diabetes and liver disease. Diabetes Care 30(3): 734-743. 2007.
Wang C, Wang X, Curg G, Ben Q, Qui W, Chen Y. et al. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review with meta-analysis of cohort studies. Inst. J cancer 130:1639-1648. 2012
Xhou XH, Qino Q, Zetherlius B, Pyrola K, Soderberg S, Payak A, et al. Diabetes, prediabetes and cancer mortality Diabetologia. 53: 1867-76, 2010.
Johnson JA, Bowker SL, Richardson K, Marra CA. Time-varying incidence of cancer after the onset of type 2 diabetes: evidence of potential detection bias. Diabetologia 54:2263-2271, 2011.
Carnestensen B, Witte DR, Frii ., Cancer occurrence in Danish diabetic patient: duration and insulin effect. Diabetologia 55: 948-958: 2012.
Connolly GC, Safadjou S, Chen R, Nduaguba A, Dunre R, Khorana et al. Diabetes mellitus is a associated with the presence of metastatic spread at disease presentation in hepatocellular carcinoma.
McGlynn KA, Quraishi S, Wetzel TM, Davilla JA, El-Serag HB.Diabetes increases the risk of hepatocellular carcinoma in the United States. Cancer Research 70(8): 1816;2010
Darik JG, Morgan RO, Shaib Y, mcGlynn KA, El-Seragg HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 54(4)..533-9, 2005.
El-Serag HB, Tran Top Everhart JE. Diabetes increase the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 126(2): 460-468, 2004.
El-Serag HB, Hampel H, Javadi F. The association between diabetes and hepatocellular carcinoma: a systematic review of epidermiological evidence. Clin gastroenterol hepatol 4(3):369-80: 2006.
Fall K, Garmo H, Gudbjornsdottir S, Stattin P, Zetherlum B. Diabetes mellitus and prostate cancer; a nationwide case control study within PCBase Sweden. Cancer Epidemol Biomarkers. Prev. 22(6): 1102-9, 2013.
Bansal D, Bhansali A, Kapli G, Undela K, Tiwon P. Type 2 DM and risk of prostate cancer: a meta-analysis of observational studies. Prostate cancer, prostatic dis. 16(2) 151-8. 2013.
Turner EL, Lane JA, Donoran JL, et la. Association of diabetes mellitus with prostate cancer.. nested case-control study. Prostate testing for cancer and treatment study). Inst. Journal of cancer 128(2): 2010.
Kasper JS, Giovannuci E. A meta-analysis of DM and the risk of prostate cancer. Cancer epidemiol biomarker of prevention 15(11): 2056-62. 2006
Barrett Connar. Lower endogenous androgenic level and dyslipidemia in men with no insulin dependent diabetes mellitus. Am J of internal medicine 112: 807-811.1992.
Werny DM, Saraija M, Greger. Prostate specific antigen values in diabetic and non diabetic US men. 2001-2002. Am J epidermiol 164:928-983.
Liao S, L, J, Wei W, Wang L, Zhang Y, L, J, Wang C, Sun S. Association between diabetic and breast cancer risk: a meta-analysis of the literature. Asian Pac J Cancer Rev. 12(4): 1061-5. 2011.
Michael KB, Solomon CG, Hu FB, et al. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses health study. Diabetes care: 26(6) 1752-1758. 2003.
Lipscombe LL, Fischer HD, Austin PC, Fu L, et al. The association between diabetes and breast cancer stage of diagnosis: a population based study. Breast cancer research and treatment. 150(3): 613-620. 2015.
Zhang H,Zhang C,Wu D. Activation of insulin-like growth factor 1 receptor regulates the radiation-induced lung cancer cell apoptosis.Immunobiology.2015
Papa V, Pezzino V,Constantino A,Belfiore A, et al elevated insulin receptor content in human breast cancer. Journal of clinical investigation.86,1503-1510,1990
Yu H, Rohan T. Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression.J Natl Can Inst 92(18):1412-1489.2000
Pollak MN. Insulin,insulin-like growth factor,insulin resistance and neoplasia..Am J clin Nutr. 86(3):8205-8215.2007
Wannathee SG, Lowe GD, Rumley A.Diabetes care.30(5):1200-1205.2007.
Zhang T,Zhang Y,Guo P, Xiong H. The Antidiabetic Drug Metformin Inhibits the Proliferation of Bladder Cancer Cells in Vitro and in vivo.Int J Mol Sci. 2013 Dec; 14(12): 24603–24618.
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