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Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes
American Journal of Internal Medicine
Volume 3, Issue 4, July 2015, Pages: 160-164
Received: May 31, 2015; Accepted: Jun. 9, 2015; Published: Jun. 25, 2015
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Authors
Sheikh Salahuddin Ahmed, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia
Tarafdar Runa Laila, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia
Fazle Nur, Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh
Mamun Ul Islam Khan, Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh
Umme Sadia Mili, Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh
Md. Abdul Mahid Khan, Department of Internal Medicine (Cardiology), Gastro Liver Hospital & Research Institute Ltd, Dhaka, Bangladesh
Mohammad Rafiqul Hoque, Department of Biochemistry, Shahid Syed Nazrul Islam Medical College, Kishoreganj, Bangladesh
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Abstract
Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.
Keywords
Glycosylated Hemoglobin, Fasting Plasma Glucose, 2 Hours After Breakfast, Diabetes Mellitus
To cite this article
Sheikh Salahuddin Ahmed, Tarafdar Runa Laila, Fazle Nur, Mamun Ul Islam Khan, Umme Sadia Mili, Md. Abdul Mahid Khan, Mohammad Rafiqul Hoque, Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes, American Journal of Internal Medicine. Vol. 3, No. 4, 2015, pp. 160-164. doi: 10.11648/j.ajim.20150304.13
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