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Outcome of Paraquat Self-poisoning a Case series
American Journal of Internal Medicine
Volume 3, Issue 6-1, November 2015, Pages: 1-4
Received: Mar. 29, 2015; Accepted: Apr. 9, 2015; Published: Oct. 23, 2015
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M Indira, Department of Medicine, Government Medical College, Thrissur, Kerala, India
Rakesh T P, Department of Medicine, Government Medical College, Thrissur, Kerala, India
Hithesh Shankar T S, Department of Forensic medicine, Government Medical College, Thrissur, Kerala, India
Suchithra E T, Department of Community medicine, Government Medical College, Thrissur, Kerala, India
Andrews M A, Department of Medicine, Government Medical College, Thrissur, Kerala, India
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Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.
Paraquat, Charcol hemoperfusion, Immunosuppressive therapy, ARDS, Renal and hepatic dysfunction
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M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A, Outcome of Paraquat Self-poisoning a Case series, American Journal of Internal Medicine. Special Issue: Toxicology. Vol. 3, No. 6-1, 2015, pp. 1-4. doi: 10.11648/j.ajim.s.2015030601.11
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