The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients
American Journal of Internal Medicine
Volume 4, Issue 2-1, March 2016, Pages: 1-4
Received: Aug. 24, 2015; Accepted: Aug. 25, 2015; Published: Oct. 25, 2015
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Authors
Eman Youssef Moursy, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Azza Abd El-Kareem Ismael, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Reham Fadl Hassan Mouftah, Department of Clinical Pathology, Faculty of Medicine, Alexandria University,Alexandria, Egypt
Eglal Saad Ghanem El-Tahan, Alexandria Fever Hospital, Ministry of Health, Alexandria, Egypt
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Abstract
Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.
Keywords
Insulin Resistance Syndrome, Beta Cell Dysfunction, Neutrophil Lymphocyte Ratio (NLR)
To cite this article
Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan, The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients, American Journal of Internal Medicine. Special Issue: Different Medical Research From Middle East. Vol. 4, No. 2-1, 2016, pp. 1-4. doi: 10.11648/j.ajim.s.2016040201.11
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