Frequency, Epidemiology and Outcome of Acute Kidney Injury Among Patients Admitted to Nephrology Center, Sana’a: Observational Study
American Journal of Internal Medicine
Volume 6, Issue 5, September 2018, Pages: 121-125
Received: Jul. 11, 2018; Accepted: Jul. 24, 2018; Published: Sep. 3, 2018
Views 1210      Downloads 93
Nagib Wazae Abuasba, Nephrology Department, Faculty of Medicine, Sana’a University, Sana’a, Yemen
Khalid Alwadee, Nephrology Department, Al Thawra Hospital, Sana’a, Yemen
Mushtaq Hasan Al-Hamadi, Nephrology Department, Al Thawra Hospital, Sana’a, Yemen
Article Tools
Follow on us
Although acute kidney injury (AKI) in our setting is growing rapidly, the available data on the magnitude of this lethal problem are very limited. The objective of this study was to determine the incidence, epidemiology and outcome of AKI. A total of 143 hospitalized patients with AKI in Al Thawra General Hospital, nephrology department between July 2015 and December 2016 were enrolled. The mean age of the study population was 37.7 ± 8.4 years, and 68.5% of these patients were males. Almost 81.8% of cases were medically referred and malarial infection was the commonest cause of AKI (23%). Pre renal AKI was present in 65 patients (45.4%) and renal AKI in 78 patients (54.5%). Most cases were presented with clinical manifestation of volume overload (65%), oliguria (51.7%), anuria (16.7%), and high serum creatinine level. The majority of cases (58.7%) had recovered without dialysis. In-hospital mortality was observed in 11 patients (7.7%). Hepatic failure and malarial infection were the common causes of death. This study demonstrates low frequency of AKI in our setting. The etiologies of this lethal health problem are preventable and treatable in approximately half of cases. Late referral to hospital may contribute both to the progression of renal disease and also to high mortality.
Acute Kidney Injury, Yemen, In-Hospital Mortality
To cite this article
Nagib Wazae Abuasba, Khalid Alwadee, Mushtaq Hasan Al-Hamadi, Frequency, Epidemiology and Outcome of Acute Kidney Injury Among Patients Admitted to Nephrology Center, Sana’a: Observational Study, American Journal of Internal Medicine. Vol. 6, No. 5, 2018, pp. 121-125. doi: 10.11648/j.ajim.20180605.15
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Krishnamurthy, S. Mondal N; Narayanan P; Biswal N;Srinivasan S; Soundravally R et al. Incidence and etiology of acute kidney injury in southern India. Indian J. Pediatr 2013; 80, 183–189.
Bhadade R, De’Souza R, Harde MJ, Mehta KS, Bhargava P. A Prospective Study of Acute Kidney Injury According to KDIGO Defi nition and its Mortality Predictors. J Assoc Physicians India. 2016; 64: 22- 28.
Abd ElHafeez S, Tripepi G, Quinn R, Naga Y, Abdelmonem S, Mohamed AbdelHady M et al. Risk, predictors, and outcomes of acute kidney injury in patients admitted to intensive care units inEgypt Scientific Reports | 7: 17163 | DOI:10.1038/s41598-017-17264-7
Magden K, Yildirim I, Kutu M, Ozdemir M, Peynir S, Altas A, Yildiz G, Hur E. Recovery process in patients followed-up due to acute kidney injury. Hippokratia 2013; 17(3):239–242.
Chawla, L. S. & Kimmel, P. L. Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int. 2012; 82, 516–524.
Uchino S, Kellum JA, Bellomo R et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294: 813–818.
Kidney Disease: Improving Global Outcomes (KDIGO). Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Inter Suppl 2012; 2:1–138.
Brown JR, Rezaee ME, Marshall EJ, Matheny ME. Hospital Mortality in the United States following Acute Kidney Injury. BioMed research international. 2016; 2016:4278579. [PMC free article] [PubMed]
Dennen P, Douglas IS, Anderson R. Acute kidney injury in the intensive care unit: An update and primer for the intensivist. Crit Care Med 2010; 38:261-275.
R. K. Hsu, C. E. McCulloch, R. A. Dudley, L. J. Lo, andC.-Y. Hsu, “Temporal changes in incidence of dialysis-requiring AKI,” Journal of the American Society of Nephrology 2013; 24(1):37–42.
Basu G, Chrispal A, Boorugu H, Gopinath KG, Chandy S, Prakash JA, et al. Acute kidney injury in tropical acute febrile illness in a tertiary care centre--RIFLE criteria validation. Nephrol Dial Transplant 2011; 26:524-31.
Jain A, McDonald HI, Nitsch D, Tomlinson L, Thomas SL. Risk factors for developing acute kidney injury in older people with diabetes and community-acquiredpneumonia: a population-based UK cohort study. BMC Nephrol 2017; 18(1): 142.
KHAN, T. M.; KHAN, K. N. M. Acute kidney injury and chronic kidney disease. Veterinary Pathology, 2015; 52(3):441-444.
Naicker S, Aboud O, Gharbi MB. Epidemiology of acute kidney injury in Africa. Semin Nephrol 2008; 28:348‑53
Saravu K, Rishikesh K, Parikh CR: Risk factors and outcomes stratified by severity of acute kidney injury in malaria. PLoS One 2014; 9:e90419.
Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, et al. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015; 10(10):1859–67. doi:10.2215/CJN.01170215.
Hickson, L. J., Chadhary, S., Williams, A. W. et al. Predictors of outpatient kidney function recovery among patients who initiate hemodialysis in the hospital. Am J Kidney Dis. 2015; 65: 592–602.
Neugarten J, Golestaneh L and Kolhe N V. Sex differences in acute kidney injury requiring dialysis. BMC Nephrology 2018; 19:131.
Posada I L, Cortés C. P, Villalva R. P, Fontana F, Romo R. R, Prieto R, et al. Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition. Sci Rep. 2017; 7: 12270 | DOI:10.1038/s41598-017-09630-2 1.
Mosa O F, Fouad M A, Zafar T A, Fahmy A M, Alyazidi F and Rizk M. Epidemiology of acute kidney injury (aki) among hospitalized and outpatients frequent to al-lieth kidney unit (AKU). Epidemiology (Sunnyvale) 7: 317. doi:10.4172/2161-1165.1000317
Bello BT, Busari AA, Amira CO, Raji YR, Braimoh RW. Acute kidney injury in Lagos: Pattern, outcomes, and predictors of inhospital mortality. Niger J Clin Pract 2017; 20:194-9.
Murugan R, Kellum JA. Acute kidney injury: what’s the prognosis. Nat Rev Nephrol 2011; 7:209–217.
Yang L. Acute kidney injury in Asia. Kidney Dis (Basel) 2016; 2(3):95–102CrossRefGoogle Scholar.
Thanachartwet V, Desakorn V, Sahassananda D, Kyaw Win KK, Supaporn T. Acute renal failure in patients with severe falciparum malaria: using the WHO 2006 and RIFLE criteria, Int J Nephrol, 2013, vol. 2013 pg. 841518.
Franzen D, Rupprecht C, Hauri D, Bleisch JA, Staubli M, Puhan MA. Predicting outcomes in critically ill patients with acute kidney injury undergoing intermittent hemodialysis – A retrospective cohort analysis. Int J Artif Organs 2010;33:15‑21.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186