Anticoagulation of Behcet’s Disease with Thrombosis: A Series of 28 Cases in a Tertiary Care Centre in Saudi Arabia
American Journal of Internal Medicine
Volume 5, Issue 4, July 2017, Pages: 57-60
Received: Mar. 30, 2017;
Accepted: Apr. 24, 2017;
Published: Jun. 15, 2017
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Muneerah Albugami, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Ahmed Al Shaikh, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Abdulaziz Alrashed, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Hanan Al Hamzi, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Alanoud Khuthaila, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Abdelazeim Elamin, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Mumin Siddiquee, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Usamah El Alem, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Lama Amer, Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Yasmin Altwaijri, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Behcet’s disease (BD) is a multisystemic inflammatory disorder of unknown etiology. There is few data about BD in Saudi Arabia. This is a retrospective chart review study of 28 patients of BD with thrombosis on long term anticoagulation. A total of 28 BD patients, their mean age was 43.8 (25-60) years. The mean age of first thrombosis was 29.2 (14-42) years. Provoked thrombosis was reported in 17.86% of the patients. The commonest site of thrombosis was superficial femoral vein 35.71%, followed by popliteal vein 32.14%, pulmonary embolism (PE) 32.14%. Anti B2 glycoprotein 1 antibodies was identified in 31.82% of patients, Anti cardiolipin Antibodies in 22.73%, Leiden factor V in 18.18%. Activity of the disease during thrombosis was recognized as oral ulcer 44.44%, genital ulcer 33.33%, Human leukocyte antigen-B (HLAB) was 32.14%. Thrombosis while patient on anticoagulation was reported in 32.14% of patients. Bleeding was reported in 14.29% of patients, common site of bleeding was gastrointestinal bleeding. Survival rate was 78.57% and 2 patients were died (7.14%) due to malignancy. Conclusion: Thrombosis in BD patients is male predominance, more in venous, has low mortality, frequency of thrombosis is more in the presence of thrombophilia and active BD. The prevalence of thrombophilia among BD patients is high. The presence of thrombophilia still affect the physician decision regarding the initiation and duration of anticoagulation in BD. The incidence of bleeding with long term anticoagulation is low. Further research is needed to find out the prevalence of cancer among BD in Saudis.
Behcet’s Disease, Anticoagulation, Trombosis, Thrombophilia
To cite this article
Ahmed Al Shaikh,
Hanan Al Hamzi,
Usamah El Alem,
Anticoagulation of Behcet’s Disease with Thrombosis: A Series of 28 Cases in a Tertiary Care Centre in Saudi Arabia, American Journal of Internal Medicine.
Vol. 5, No. 4,
2017, pp. 57-60.
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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