Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway
American Journal of Internal Medicine
Volume 5, Issue 4, July 2017, Pages: 52-56
Received: Mar. 28, 2017; Accepted: Apr. 10, 2017; Published: Jun. 15, 2017
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Lan Xian-wu, Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China
Cui Liang, Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China
Gui Wen-shan, Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China
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Objective To observe the abnormal expression of IL-1βin hippocampus after bilateral common carotid artery ligation and to evaluate its effects on memory impairment induced by chronic cerebral ischemia. Methods Bilateral common carotid artery ligation (2-vessel occlusion, 2VO) was performed in wild type (Wild Type WT) and interleukin -1 receptor knock-out (IL-1 Resept Knock Out, IL-1R KO) C57 mice (male) to produce chronic cerebral ischemia mouse models. After the operation, their memory was detected with eight-arm radial maze test and the novel object recognition test, and the level of IL-1β and BDNF in hippocampus was detected with Western Blot. Results The average number of working memory errors of the KO-2VO mice was significantly decreased (P<0.05), and the recognition index was significantly increased (P<0.05) compared with those of the WT-2VO mice. Dramatic decrease in IL-1β in hippocampus (P<0.05) and substantial increase in BDNF (P<0.05) were observed in the KO-2VO mice. In the behavioral experiment and Western Blot, there was no significant difference between the KO-sham mice and the WT-sham controls. Conclusion Increase in the level of the IL-1β in hippocampus after bilateral common carotid artery ligation can lead to decrease in the level of the BDNF, which may cause memory impairment.
Chronic Cerebral Ischemia, Bilateral Common Carotid Artery Ligation, Microglia, Interleukin-1β,Brain-Derived Neurotrophic Factor (BDNF), Working Memory Impairment
To cite this article
Lan Xian-wu, Cui Liang, Gui Wen-shan, Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway, American Journal of Internal Medicine. Vol. 5, No. 4, 2017, pp. 52-56. doi: 10.11648/j.ajim.20170504.11
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