Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites
American Journal of Internal Medicine
Volume 5, Issue 1, January 2017, Pages: 12-17
Received: Jan. 1, 2017; Accepted: Jan. 20, 2017; Published: Feb. 20, 2017
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Ahmed A. Obiedallah, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Essam Abdelmohsen, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Abdalla I. Kelani, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Mohamed Mousa, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
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Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.
Midodirine, Refractory Ascites, Liver Cirrhosis
To cite this article
Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa, Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites, American Journal of Internal Medicine. Vol. 5, No. 1, 2017, pp. 12-17. doi: 10.11648/j.ajim.20170501.13
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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