Study the Efficacy of Budesonide Enema in Treating Collagenous Microscopic Colitis: An Egyptian Trial
American Journal of Internal Medicine
Volume 3, Issue 6, November 2015, Pages: 238-244
Received: Oct. 27, 2015; Accepted: Nov. 4, 2015; Published: Nov. 17, 2015
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Marwa Ahmed Saad Gouda, Internal Medicine Department, Geriatric Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Ahmed Ismail Al-lakani, Internal Medicine Department, Gastroenterology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Magdy Mohammed Bedewy, Histo-Pathology Department, Military Academy Hospital, Alexandria, Egypt
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Chronic diarrhea can have a substantial impact on the patient’s quality of life and overall health. Microscopic colitis (MC) is an inflammatory bowel disease, which is characterized by chronic watery diarrhea. Many drugs, including steroids, had emerged to treat MC. Our aim was testing the efficacy of Budesonide enema in improvement of patients with collagenous microscopic colitis both clinically and histo-pathologiclly. 22 patients with active microscopic colitis were enrolled in the present study, 15 women, and 7 men, with mean age of 60.9±8.5 years. Mean duration of symptoms was 2.6±0.8 years. Patients were given Budesonide enema 2mg/100ml twice daily for 2 weeks then, once daily for 4 weeks. They were evaluated both clinically and histopathologically after 6 weeks.18 patients (81.8%) showed high statistically significant decrease in the thickness of collage layer, and degree of inflammation. The patients’ frequency of stool decreased from 7.6±1.0 to 2.7±1.6 motions/day (p<0.001), and also consistency of stool improved (p<0.001).We concluded that Budesonide enema in a dose of 2 mg/100ml was well tolerated and effective in induction of remission in active collagenous colitis. Effects on both clinical symptoms and inflammatory infiltrate were seen. Recurrence rate after stopping treatment is moderate. Non-responders may need prolonged duration of treatment or omitting the drugs that may be responsible for colonic inflammation.
Chronic Diarrhea, Collagenous Colitis, Budesonide Enema
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Marwa Ahmed Saad Gouda, Ahmed Ismail Al-lakani, Magdy Mohammed Bedewy, Study the Efficacy of Budesonide Enema in Treating Collagenous Microscopic Colitis: An Egyptian Trial, American Journal of Internal Medicine. Vol. 3, No. 6, 2015, pp. 238-244. doi: 10.11648/j.ajim.20150306.14
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