The Potential Roles of Superoxide Dismutase, Matrix-Metalloprotinase-9 and Interlukine -18 with the Prevalence and Progression of Type II Diabetes Mellitus
Background and Objectives: Type II diabetes mellitus is becoming the most important health problems. It is important to find new pathogenic pathways to provide opportunities for early diagnosis and targets for novel treatments. Aims: to investigate the effect of type II diabetes mellitus on serum levels super oxide dismutase as a potential biomarkers of oxidant /antioxidant imbalance, matrix-metaloprotinase-9, and interlukine -18 as an inflammatory biomarkers and estimated their relationships with prevalence and progression of disease, to find out the effects of other confounding factors severity of disease, gender, and age on the serum interested parameters levels, finally detected the correlation coefficient between the studied parameters. Methods: This study was designed to examine the associations between the parameters with the prevalence and progression of disease in 50 patients, and an equal number of matched age –gender healthy adults were also enrolled in this study as a control group. The hypothesis of the study stated that oxidant /antioxidant imbalance and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. To elucidate this hypothesis, the parameters were investigated using enzyme linked immunosorbent assay. Statistical Analyses: All analyses were performed with SPSS version 18. Results: Patients showed a significant variations in the serum focused parameters levels. The level of superoxide dismutase in patient and control groups were (301.684 ±97.041), (501.447 ±162.781) (ng/ml) respectively. The level of matrix–metalloprotinase-9 in patient and control groups were (2.632 ± 1.745), (1.506± 0.945) ng/ml respectively. The level of interlukine -18 in patients and control groups were (93.996 ±21.297), (48.400 ±26.375) (pg/ml) respectively. Conclusions: The prevalence of type II diabetes mellitus in the Erbil population constitutes a major health problem. Oxidative stress is increased in type II diabetes mellitus and this finding may explain the role of oxidant /antioxidants status imbalance leading to significant reduction in the serum superoxide dismutase level concomitant with increased inflammatory process leading to significant elevation of matrix- metaloptotinase-9 and interlukine -18, and these findings added a prognostic information to type II diabetes mellitus. Data demonstrated a highly significant association between the variation in the serum parameters levels with prevalence and progression of the disease. Accordingly, these parameters have been evaluated as potential tools for type II diabetes mellitus risk prediction. It can therefore be concluded that hyperglycemia influences the etiopathogenesis of type II diabetes mellitus.
Shwan Ali Umar,
Shatha Rouf Moustafa,
The Potential Roles of Superoxide Dismutase, Matrix-Metalloprotinase-9 and Interlukine -18 with the Prevalence and Progression of Type II Diabetes Mellitus, American Journal of Internal Medicine.
Vol. 3, No. 3,
2015, pp. 103-116.
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