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Prevalence of Hookworm Infection: A Retrospective Study in Kumasi, Ghana
Science Journal of Public Health
Volume 2, Issue 3, May 2014, Pages: 196-199
Received: Apr. 9, 2014; Accepted: Apr. 24, 2014; Published: Apr. 30, 2014
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Williams Walana, Department of Clinical Laboratory Sciences, School of Medicine and Health Sciences, University for Development Studies (UDS), Tamale, Ghana
Eric Nana Kofi Aidoo, Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Ezekiel Kofi Vicar, Department of Clinical Laboratory Sciences, School of Medicine and Health Sciences, University for Development Studies (UDS), Tamale, Ghana
Samuel Crowther Kofi Tay, Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
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Introduction- Epidemiological information such as trends of prevalence of hookworm infection is a prerequisite to developing and/or sustaining control strategies. Objective- This study specifically sought to establish the prevalence of hookworm infection among patients who reported at the Parasitology Laboratory of the Komfo Anokye Teaching Hospital (KATH) for intestinal parasitic investigation. Method- A retrospective study conducted covered available data from January 2001 to December 2011. Records of patients referred to the Parasitology Laboratory of the hospital were manually reviewed for hookworm infection. Data on age, sex and status of hookworm infection (either present or absent) were retrieved and analyzed using Microsoft excel 2007 statistical package. Results- A total of 47147 patients reported at the laboratory for intestinal parasitic investigations. Out of this number, 158 were hookworm positive, representing an overall prevalence of 0.3% (158/47147). Among the positive cases, the study revealed that the proportion of individuals in age groups <1, 1 to 9, 10 to 19, 20 to 29, and 30 to 39 years infected were 1.3%(2), 10.8%(17), 16.5%(26), 27.2%(43) and 23.4%(37) respectively. However, the proportion of patients in age groups 40 to 49, 50 to 59 and ≥60 years infected were 8.7%(14), 5.7%(9) and 7.0%(11) respectively. Among the infected patients 62.7% (99) were females while 37.3% (59) were males. The yearly prevalence rate dropped consistently from 0.8% in 2001 to 0.1% in 2005. It however increased marginally in 2006 (0.3%) and dropped to 0.0% in 2011. There were indications of seasonal variation regarding the monthly prevalence rates of hookworm infection. Conclusion- The overall prevalence of hookworm was relatively low among the study population. However, the study suggests that hookworm infestation is generally high between April and August.
Hookworm, Infection, Prevalence
To cite this article
Williams Walana, Eric Nana Kofi Aidoo, Ezekiel Kofi Vicar, Samuel Crowther Kofi Tay, Prevalence of Hookworm Infection: A Retrospective Study in Kumasi, Ghana, Science Journal of Public Health. Vol. 2, No. 3, 2014, pp. 196-199. doi: 10.11648/j.sjph.20140203.19
Ranjit N, Bin Zhan B, Hamilton B, Stenzel D, Lowther J, Pearson M et al. Proteolytic Degradation of Hemoglobin in the Intestine of the Human Hookworm. Necator americanus. J Infect Dis. 2009; 199 (6): 904-912.
Pearson MS, Pickering DA, Tribolet L, Cooper L, Mulvenna J, Oliveira LM et al. Neutralizing Antibodies to the Hookworm Hemoglobinase Na-APR-1: Implications for a Multivalent Vaccine against Hookworm Infection and Schistosomiasis. J Infect Dis. 2010; 201(10): 1561-1569.
Hotez PJ, Bethony JM, Diemert DJ, Pearson M, Loukas A. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. In: Institute of Medicine (US) Forum on Microbial Threats. The Causes and Impacts of Neglected Tropical and Zoonotic Diseases: Opportunities for Integrated Intervention Strategies. Washington (DC): National Academies Press (US); 2011. A9.
Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Sangweme D, Chirehwa MT, Brouwer KC et al. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe. Acta Tropica. 2010; 115(1–2): 103–111.
Hotez PJ. Mass drug administration and integrated control for the world's high-prevalence neglected tropical diseases. Clin. Pharmacol. Ther. 2009; 85:659–664. doi: 10.1038/clpt.2009.16.
Ngui R, Lim YAL, Chong Kin L, Sek Chuen C, Jaffar S. Association between Anaemia, Iron Deficiency Anaemia, Neglected Parasitic Infections and Socioeconomic Factors in Rural Children of West Malaysia. PLoS Negl Trop Dis. 2012; 6(3): e1550. Doi:10.1371/journal.pntd.0001550.
Shaw JG, Friedman JF. Iron deficiency anemia: focus on infectious diseases in lesser developed countries. Anemia. 2011; 260380. doi: 10.1155/2011/260380.
Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. J Clin invest. 2008;118:1311–1321.
WHO Worldwide prevalence of anaemia 1993–2005. In: de Benoist B, McLean E, Egli I, Cogswell M, editors. WHO global database on anaemia. Geneva: 2008; World Health Organization.
Hotez PJ. Hookworm and poverty. Ann. N. Y. Acad. Sci. 2008; 1136: 38–44.
Hotez PJ. The development impact of the neglected tropical diseases (NTDs). United Nations Department of Economic and Social Affairs Population Division. Expert Paper No. 2011/1. 2011; p1-40.
Brooker S. Estimating the global distribution and disease burden of intestinal nematode infections: Adding up the numbers – A review. Int J Parasitol. 2010; 40(10): 1137–1144. doi: 10.1016/j.ijpara.2010.04.004
MOH/GHS (2006), Two-year Strategic Plan for Integrated Neglected Tropical Diseases Control in Ghana, 2007-2008, p 1-41.
Cheesbrough M. District Laboratory Practice in Tropical Countries, Cambridge University Press, Cambridge, UK, 2005.
Tadesse G. The prevalence of intestinal helminthic infections and associated risk factors among school children in Babile town, eastern Ethiopia. Ethiop.J.Health Dev.2005; 19(2): 140-147.
Yatich NJ, Yi J, Agbenyega T, Turpin A, Rayner JC, Stiles JK. Malaria and intestinal helminth co-infection among pregnant women in Ghana: prevalence and risk factors. Am J Trop Med Hyg. 2009; 80(6): 896-901.
Febriani Y, Levallois P, Gingras S, Gosselin P, Majowicz SE, Fleury MD. The association between farming activities, precipitation, and the risk of acute gastrointestinal illness in rural municipalities of Quebec, Canada: a cross-sectional study. BMC Public Health 2010; 10(48). doi:10.1186/1471-2458-10-48.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D et al. Soil transmitted helminth infections; ascariasis, trichuriasis, and hookworm, Lancet 2006; 367(9521):1521-32.
Akinbo FO, Okaka CE and Omoregie R. Seasonal variation of intestinal parasitic infections among HIV-Positive patients in Benin City, Nigeria. Ethiop. J. Health. Sci. 2011; 21(3): 191–194.
Siwila J, Isaac P, Heidi Larsen E, Mbiko N, Annette O. Seasonal prevalence and incidence of Cryptosporidium spp. and Giardia duodenalis and associated diarrhoea in children attending pre-school in Kafue, Zambia. Trans R Soc Trop Med Hyg 2011; 105:102-108.
Verhagen LM, Incani RN, Franco CR, Ugarte A, Cadenas Y, Ruiz SIC et al. High Malnutrition Rate in Venezuelan Yanomami Compared to Warao Amerindians and Creoles: Significant Associations WITH Intestinal Parasites and Anemia. PLoS ONE 2013; 8(10): e77581. doi:10.1371/journal.pone.0077581.
Rayan P, Verghese S, McDonnel PA. Geographical locations and age affects the incidence of parasitic infestations in school children. Ind. J. Patho& Microb. 2010; 53(3): 498-502.
Mbae CK, Nokes DJ, Mulinge E, Nyambura J, Waruru A, Kariuki S et al. Intestinal parasitic infections in children presenting with diarrhoea in outpatient and inpatient settings in an informal settlement of Nairobi, Kenya. BMC Infectious Diseases 2013, 13:243. doi:10.1186/1471-2334-13-243.
Osazuwa F, Ayo OM, Imade P. A significant association between intestinal helminth infection and anaemia burden in children in rural communities of Edo state, Nigeria. North Am J Med Sci. 2011; 3: 30–34. doi: 10.4297/najms.2011.330.
Brooker S, Jardim-Botelho A, Quinnell RJ, Geiger SM, Caldas RS, et al. (2008) Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Trans R Soc Trop Med Hyg. 2008; 101: 146–154. doi: 10.1016/j.trstmh.2006.05.012.
Abu-Madi MA, Behnke JM, Doiphode SH. Changing trends in intestinal parasitic infections among long-term-residents and settled immigrants in Qatar. Parasites & Vectors 2010; 3:98. doi:10.1186/1756-3305-3-98.
Rayan P, Verghese S, McDonnel PA. Geographical locations and age affects the incidence of parasitic infestations in school children. Ind. J. Patho& Microb. 2010; 53(3): 498-502.
Lim YA, Romano N, Colin N, Chow SC, Smith HV. Intestinal parasitic infections amongst Orang Asli (indigenous) in Malaysia: has socioeconomic development alleviated the problem? Trop Biomed. 2009; 26(2):110-122.
Phongluxa K, Xayaseng V, Vonghachack Y, Akkhavong K, van Eeuwijk P, Odermatt P. Helminth infection in southern Laos: high prevalence and low awareness. Parasites & Vectors 2013, 6:328. doi:10.1186/1756-3305-6-328.
Nasr NA, Al-Mekhlafi HM, Ahmed A, Roslan MA, Bulgiba A. Towards an effective control programme of soil-transmitted helminth infections among Orang Asli in rural Malaysia. Part 1: prevalence and associated key factors. Parasit Vectors. 2013; 6(27). doi: 10.1186/1756-3305-6-27.
Okwa OO. Tropical Parasitic Diseases and Women. Annals of African Medicine. 2007; 6(4): 157 – 163.
Walker M, Hall A, Basáñez M-G. Individual Predisposition, Household Clustering and Risk Factors for Human Infection with Ascaris lumbricoides: New Epidemiological Insights. PLoS Negl Trop Dis. 2011; 5(4): e1047. doi:10.1371/journal.pntd.0001047.
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