Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease
Science Journal of Public Health
Volume 5, Issue 6, November 2017, Pages: 469-473
Received: Dec. 5, 2017;
Published: Dec. 6, 2017
Views 67 Downloads 4
Yuzhi Liu, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhenjiang Hou, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Jingyu Zhang, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Jianzhang Hou, Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China
Hongsheng Wang, Diabetes Department of Endocrinology, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.
Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease, Science Journal of Public Health.
Vol. 5, No. 6,
2017, pp. 469-473.
Chu XQ, Liu C. New thoughts on pathological factors of hypothyroidism. Chin J Prac Inter Med, 2014, vol. 34, pp. 313-316.
Bensenor IM, Olmos RD, Lotufo PA. Hypothyroidism in the elderly: diagnosis and manage ment. Clin Interv Aging, 2012, vol. 7, pp.97-111.
Lioudaki E, Mavroeidi NG, Mikhailidis DP, et al. Subclinical hypothyroidism and vascular risk:an update. Hormones (Athens), 2013, vol. 12, pp.495-506.
Kamasaki H, Takeuchi T, Mikami T, et al. A case of graves’ disease diagnosed in the course of bilateral carotid artery stenoses (moyamoya disease );a case report and review of the literature. Clin Pediatr Endocrinol, 2013, vol. 22, pp. 39-44.
Rotondi M, Magri F, Chiovato L. Risk of coronary heart disease and mortality for adults with subclinical hypothy-roidism.JAMA, 2010, vol. 304, pp. 2481.
Schaffer A, Verdoia M, Cassetti E, et al. Relationship between homocysteine and coronary disease, Results from a large prospective cohort study. Thromb Res, 2014, vol. 134, pp. 288-293.
Zhou CJ, Zhu XL, Wang CG, et al.. The diagnosis value of combined detection of TH and Hcy levels for patients with hypothyroidism. Chin J Health Lab Tec, 2016, vol. 26, pp. 2205-2207.
Tseng FY, Lin WY, Lin CC, et al. Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol, 2012, vol.60, pp. 730-737.
Fu YL, Fan LM. Research progress on the correlation between thyroid function and metabolic syndrome. J Mod Med Health, 2017, vol. 33, pp.77-79.
Song QZ, Xu FL, Bi XP, et al. Clinical significance of serum hom ocysteine and lipids determ ination in hypothyroi-dism. Lab Med, 2007, vol. 22, pp. 176-178.
Toruner F, Altinova AE, Karakoc A, et al. Risk factorsfor cardiovascu1ar disease in patients with subclinical hypothyroidism. Adv Ther, 2008, vol. 25, pp. 430-437.
van Tienhoven-Wind LJ, Dullaart RP. Low-normal thyroid function and the pathogenesis of commoncardio-metabolic disorders. EurJClin Invest, 2015, vol. 45, pp. 494-503.
Liu CH, Xiao JX. To investigate the correlation between subclinical hypothyroidism and coronary heart disease. Prac Clin J Inte Tradi Chin Wes Med, 2016, vol. 16, pp.40-41.
Liu W, Pan M, Wu XH. Effect of subclinical hypothyroidism on metabolism factors in elderly patients with coronary heart disease. Chin J Clin Health, 2015, vol. 18, pp. 354-356.
Wang C, Zhang P. The clinical study of blood lipid ratio in predicting cardiovascular diseaseProgress. Shandong J Med, 2015, vol. 36, pp. 99-102.
Xie YJ. The level and significance of serum lipid index in patients with different types of coronary heart disease. Contemporary Med, 2012, vol. 18, pp. 10-11.
Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, et al. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. American Journal of Clinical and Experimental Medicine, 2017, vol. 5, pp. 108-114
Wu ZR, Zhang LR, Pan YQ et al. Changes and clinical significance of serum homocysteine and lipids in Patients with primary hypothyroidism and hyperthyroid. Prog Mod Bio, 2009, vol. 22, pp. 4276-4278.
Xiong L, Luo CD, Liu YB, et al. Changes of Plasma Homocysteine and Peripheric Arterial Stiffness in Patients with Subclinical Hypothyroidism. West Chin J Med, 2015, vol. 30, pp. 2205-2207.