Beta-lactamases and Their Global Health Implications-Two: Resistance Profile and Global Health Risk
Science Journal of Public Health
Volume 3, Issue 5, September 2015, Pages: 797-803
Received: Sep. 4, 2015; Accepted: Sep. 23, 2015; Published: Oct. 19, 2015
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Authors
Sunday Akidarju Mamza, Department of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Godwin Onyemaechi Egwu, Department of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Gideon Dauda Mshelia, Department of surgery and Theriogenology, University of Maiduguri, Maiduguri, Nigeria
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Abstract
Beta-lactamases are enzymes produced by some bacteria, which make them resistant to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins and carbapenems. In this article, global health implications, resistance profile and treatment options were reviewed. Extended-spectrum β–lactamases produced by enterobacteria and methicillinases produced by Staphylococci have been shown to constitute the growing strains of bacteria that confer resistances to all β–lactam agents and many non–β–lactam antimicrobials, including fluoroquinolones. Their continued detection in animal species and food products poses a great challenge to diagnosis and treatment of resulting infections, thus, emanating to serious global health implications. Although a lot of works on β-lactamases have been directed towards the search for molecules which can inhibit these enzymes, the beta-lactamase producting bacteria are not leaving any stone to chance. Investigations targeted at identifying the carriers of these enzymes and intercepting their transmission will help curb the emergence and spread of the β–lactamases and their menace to public health.
Keywords
Beta-lactamase, Escherichia coli, Staphylococcus aureus, Epidemiology, Resistance, Health Implications
To cite this article
Sunday Akidarju Mamza, Godwin Onyemaechi Egwu, Gideon Dauda Mshelia, Beta-lactamases and Their Global Health Implications-Two: Resistance Profile and Global Health Risk, Science Journal of Public Health. Vol. 3, No. 5, 2015, pp. 797-803. doi: 10.11648/j.sjph.20150305.39
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