Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure
Biochemistry and Molecular Biology
Volume 3, Issue 6, November 2018, Pages: 71-76
Received: Oct. 31, 2018;
Accepted: Dec. 17, 2018;
Published: Jan. 16, 2019
Views 856 Downloads 138
David Morakinyo Sanni, Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Oluwasegun Victor Omotoyinbo, Department of Biological Sciences, Wesley University, Ondo, Nigeria
Damilola Folajimi, Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.
David Morakinyo Sanni,
Oluwasegun Victor Omotoyinbo,
Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure, Biochemistry and Molecular Biology.
Vol. 3, No. 6,
2018, pp. 71-76.
Bacq, Y. (2013). The Liver in Normal Pregnancy. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Bacq, Y., Zarka, O., Brechot, J. F., Mariotte, N. and Vol, S. (1996). Liver function tests in normal pregnancy: A prospective study of 103 pregnant women and 103 matched controls. Hepatology 23: 1030-1034.
Bertil, E andGlader, A. (2002). A review on genetics and Pathophysiology of Glucose-6-Phosphate Dehydrogenate deficiency. Blood 15: 150.
Beutler, E. (1994). G6PD deficiency. Blood 84 (11): 3613-3636.
Bygbjerb, L. C. and Flash, H. (2001). Effects of chloroquine on human lymphocyte proliferation. Tran Soc Tro Med Hyg 80: 231-235.
Devarbhavi, H., Alvares, J. F. and Kumar, K. S. (2005). Severe falciparum malaria simulating fulminant hepatic failure, Mayo Clin Proc 80: 355-358.
Fisayo, A. M. (2007). Plasma proteins and proteinuria in gestational malaria. Indian J Clin Biochem. 22 (2):93-5.
Glader, B. E. (2016). A review on genetics and Pathophysiology of Glucose-6-Phosphate Dehydrogenate deficiency. Wolters Kluwer; UpToDate.
Ignatius, C. M., Emeka, E. N. and Blessing, N. E. (2008). Effect of malaria parasitemia on liver enzymes tests. International Journal of Trop Med 3: 49-52.
Kawamoto, R., Ninomiya, D., Hasegawa, Y., Kasai, Y., Kusunoki, T., Ohtsuka, N., Kumagi, T. and Abe, M. (2014). Mildly Elevated Serum Bilirubin Levels Are Negatively Associated with Carotid Atherosclerosis among Elderly Persons. PLoS ONE, 9 (12), 1-14.
Kondrackiene, J. and Kupcinskas, L. (2008). Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems. World Journal of Gastroenterology; 14 (38), 5781–5788.
Luzzato, L. and Mehta, A. (2001). Glucose-6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease, 8th ed. New York: McGraw-Hill, 45: 17-53.
Mackillop, L. and Williamson, C. (2010). Liver disease in Pregnancy. Postgrad Med J. 86 (1013):160-4.
Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D. and Robbins TW. (2000). Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci. 20 (6):RC65.
Moss, D. W and Handerson, A. R. (1999). ClinicalEnzomology. In: Burtis, C. A. and F. R. Ashwood, (Eds.), Tietz Textbook of clinical chemistry. 3rd Edn., Saunders Co., Philadelphia, W. B., pp: 617-721.
Nour, A. H., Nour, Ab. H., Sandanasamy, J. A. P. and Yusoff, M. M. (2012). Antibacterial Activity of Different Extracts of SwieteniaMacrophylla King. Proceedings of the 13th Seminar on Medicinal and Aromatic Plants, 25-26 September 2012, Kuala lumbur, Malaysia, pp. 17-18.
Odhiambo, C., Omolo, P., Oyaro, B., Williamson, J., Kinuthia, J., Matemo, D., Drake, A., John-Stewart, G. and Zeh, C. (2017). Establishment of reference intervals during normal pregnancy through six months postpartum in western Kenya. PLoS ONE, 12 (4): 1-11.
Owusu, R., Asante, K. P., Mahama, E., Awini, E., Anyorigiya, T., Dosoo, D., Amu, A., Jakpa, G., Ofei, E., Segbaya, S., Oduro, A. R., Gyapong, M., Hodgson, A., Bart-Plange, C. and Owusu-Agyei, S. (2015). Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin drop after Sulphadoxine-Pyrimethamine use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana – A Cohort Study. PLoS ONE 10 (9): 1-17.
Peters, A. L. and Van Noorden, C. J. F. (2009). Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women. J. Histochemistry and Cytochemistry, 57 (11), 1003–1011.
Prakash, J. (2012). The kidney in pregnancy: A journey of three decades. Indian Journal of Nephrology, 22 (3), 159–167.
Prchal, J. T. (2005). Polycythemia vera and other primary polycythemias. Curr. Opin. Hemat. 12: 112-116.
Reclos, G. J., Hatzidakis, C. J. and Schulpis, K. H. (2000). Glucose-6-phosphate dehydrogenase deficiency neonatal screening: Preliminary evidence that a high percentage of partially deficient female neonate are missed during routine screening. J Med Screen 7:46-51.
Seong, W. J., Chong, G. O., Hong, D. G., Lee, T. H., Lee, Y. S., Cho, Y. L., Chun, S. S. and Park, I. S. (2010). Clinical significance of serum albumin level in pregnancy-related hypertension. J Obstet Gynaecol Res. 36 (6):1165-73.
WHO Scientific Group (1967). Standarization procedures for the study of glucose-6-phosphate dehydrogenase. WHO Tech Rep. 366, 1-8.
WHO Working Group. (1989). Glucose-6-phosphate dehydrogenase deficiency. Bulletin of the World Health Organization, 67 (6), 601–611.
Zaffanello, M., Rugolotto, S., Zamboni, G., Gaudino, R. and Tatò, L. (2004). Eur J Epidemiol. 19: 255-257.