American Journal of Laboratory Medicine
Volume 4, Issue 2, March 2019, Pages: 35-39
Received: Mar. 15, 2019;
Accepted: Apr. 22, 2019;
Published: May 9, 2019
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Sona Appukutty, Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Silvana Di Palma, Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Stephen Whitaker, Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Katie Wood, Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.
Silvana Di Palma,
Olfactory Neuroblastoma Presenting as a Submandibular Mass, American Journal of Laboratory Medicine.
Vol. 4, No. 2,
2019, pp. 35-39.
Berger L, Luc H, Richard D. L’esthesioneuroepitheliome olfactif. Bull Assoc Fr Etude Cancer 1924; 13: 410-21.
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. Lyon: IARC 2017.
Hamilton AE, Rubinstein LJ, Poole GJ. Primary intracranial esthesioneuroblastoma, (olfactory neuroblastoma). J Neurosurg 1973; 38: 548-56.
Mariani L, Schaller B, Weis J, Ozdoba C, Seiler RW. Esthesioneuroblastoma of the pituitary gland: a clinicopathological entity? Case report and review of the literature. J Neurosurg 2004; 101: 1049-52.
Rinaldo R, Ferlito A, Shaha AR, Wei WI, Lund VJ. Esthesioneuroblastoma and cervical lymph node metastases: clinical and therapeutic implications. Acta Otolaryngol 2002; 122: 215-21.
Howell MC, Branstetter IV BF, Snyderman CH. Patterns of regional spread for esthesioneuroblastoma. Am J Neuroradiol 2011; 32: 929-33.
Nalavenkata SB, Sacks R, Adappa ND, Palmer JN, Purkey MT, Feldman MD, Schlosser RJ, Synderman CH, Wang EW, Woodworth BA, Smee R, Havas TE, Gallagher R, Harvey RJ. Olfactory neuroblastoma: Fate of the neck - A long term multicenter retrospective study. Otolaryngol Head Neck Surgery 2016, Vol. 154 (2): 383-9.
Konig M, Osnes T, Jebsen P, Evensen JF, Meling TR. Olfactory neuroblastoma: a single-centre experience. Neurosur Rev 2018; 41 (1): 323-331.
Chatterjee T, Muller, MF, Meier B. Cardiac metastasis of an esthesioneuroblastoma. Heart 1997; 77: 82-83.
Shetty SC, Gupta S, Chary G, Shariff S, Acharaya V, Belliappa MS. Olfactory neuroblastoma metastatic to the breast. Rhinology 2000; 38 (3): 144-6.
Mrad K, Mansouri D, Driss M, Sassi S, Abbes I, Ben Ayed F, Romdhane KB. Esthesioneuroblastoma metastatic to the breast in a young woman. Acta Cytol. 2005; 49 (4): 427-30.
Bachar G, Goldstein DP, Shah M, Tandon A, Ringash J, Pond G, Gullane PJ, Perez-Ordonez B, Gilbert RW, Brown DH, Gentilli F, O’Sullivan B, Irish JC. Esthesioneuroblastoma: The Princess Margaret Hospital experience. Head Neck 2008; 30 (12): 1607-1614.
Mattavelli F, Pizzi N, Pennacchioli E, Radaelli S, Calarco G, Quattrone P, Patelli L, Spinelli P. Esthesioneuroblastoma metastatic to the trachea. Acta Otorhinolaryngologica Italica 2009; 29: 164-168.
Chew YK, Cheong JP, Brito-Mutunayagam S, Khir A, Prepageran N, Mun KS. Subcutaneous metastasis of olfactory neuroblastoma – an uncommon presentation. Med J Malaysia 2011; Vol 66 no 1.
Tural D, Yildiz O, Selcukbiricik F, Ozturk MA, Keles Y, Oz B, Uzel O, Demir G, Mandel NM. Olfactory Neuroblastoma: An experience of 24 years. ISRN Oncology volume 2011, article ID 451086, 7 pages.
Larbcharoensub N, Kanoksil W, Cheewaruangroj W, Wiratkapun C, Sitathanee C, Sirachainan E. Oncology letters 2014; 8: 1505-1508.
Ilson, S., Schorwer, M., Frelinghuysen, M., Platin, E., Delgado, C., & Mucientes, F. Esthesioneuroblastoma metastatic to the neck and lung: a case report and review of the literature. Memo - Magazine of European Medical Oncology. 2015; 8 (2), 152-155.
Buohliqa L, Upadhyay S, Nicolai P, Cavalieri R, Dolci RLL, Prevedello D, Carrau RL. Possible esthesioneuroblastoma metastasis to paranasal sinuses: Clinical report and literature review. Head & Neck 2016; E32-E36.
Banuchi V, Dooley L, Lee NY, Pfister DG, McBride S, Riaz N, Bilsky MH, Ganly, Shah JP, Kraus DH, Morris LG. Patterns of regional and distant metastasis in esthesioneuroblastoma. Laryngoscope. 2016; 126 (7): 1556-61.
Hussaini AS, Dombrowski JJ, Bolesta ES, Walker RJ, Varvares MA. Esthesioneuroblastoma with bilateral metastases to the parotid glands. Head Neck 2016 Jul; 38 (7): E2457-E2460.
Rahman M, Okada AR, Guan K, Tauchi-Nishi P. Metastatic neoplasms to the thyroid diagnosed by fine-needle aspiration/core biopsy: Clinicopathologic and cytomorphologic correlation. Cytojournal 2017; 14: 16.
Hyams, VJ. Tumors of the upper respiratory tract and ear. In: Hyams, VJ, Batsakis, JG, Michaels, L, editors. Atlas of tumor pathology. Second series, fascicle 25. Washington (DC): Armed Forces Institute of Pathology; 1988. p. 240—8
Kadish S, Goodman M, Wang CC. Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 1976; 37 (3): 1571–6.
Dulguerov P, Calcaterra T. Esthesioneuroblastoma: the UCLA experience 1970-1990. Laryngoscope 1992; 102: 843-849.
Gnepp DR, Corio RL, Brannon RB. Small cell carcinoma of the major salivary glands. Cancer 1986; 58 (3): 705-14.
Said-Ai-Naief N, Sciandra K, Gnepp DR. Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the parotid gland: report of three cases with contemporary review of salivary neuroendocrine carcinomas. Head and Neck Pathology 2013: 7 (3): 295-303.
Meacham R, Matrka L, Ozer E, Ozer HG, Wakely P, Shah M. Neuroendocrine carcinoma of the head and neck: a 20-year case series. Ear Nose Throat J. 2012; 91 (3): E20-4.
Salama AR, Jham BC, Papadimitriou JC, Scheper MA. Metastatic neuroendocrine carcinomas to the head and neck: report of four cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108 (2): 242-7.
Gulati A, Ramchandani PL, King EV. Carcinoid tumour metastasis to the submandibular gland: a case report. Ann R Coll Surg Engl. 2011; 93 (6): 67-8.