There is a strong link between asthma and metabolic syndrome. This relationship has been shown by various researchers. A bidirectional relationship exists between asthma and metabolic syndrome. The aim of this study was to access the correlation between metabolic syndrome and asthma Using internet search, a comprehensive literature review was done and words such as asthma, respiratory problems, chronic obstructive pulmonary diseases, metabolic syndrome, obesity, insulin resistance were searched from Google scholar, Yahoo, Pubmed, Medline, Web MD, Scopus to check for various articles published on this subject. The references of the relevant articles were also searched. Analyses of results of various studies from various parts of the world were considered and their prevalences were noted to access the correlation between asthma and metabolic syndrome. Obesity, which is a component of metabolic syndrome is a risk factor for asthma. This study concludes with evidences from various studies that there is a strong link between asthma and metabolic syndrome.
Ekpe Ekpe Lawson,
Asthma and Metabolic Syndrome–Correlation and Review of Literature, American Journal of Laboratory Medicine.
Vol. 1, No. 1,
2016, pp. 1-4.
Garmendra JV, Moreno D, Garcia AH, De Sanctis JB. Metabolic syndrome and asthma. Recent Pat Endocr Metab Immune Drug Discor. 2014; 8(1): 60-6.
Luraia Serafino Agnesa, Maria Spatafora, Nicole Scichilone. Asthmma and Metabolic Syndrome- current knowledge and future perspectives. World J Clin Cases. 2015, 16: 3(3): 285-292.
Global Strategy for Asthma Management and Prevention. Global initiative for Asthma (GINA) 2012. Available from http: // www. ginasthma.org
Program NAEAP. Expert Panel Report 3 (EPR-3). Guidelines for the diagnosis and management of Asthma-summary Report 2007. J Allergy Clin Immunol. 2007, 120: 594-38.
Uzunlulu M, Oguz A, Gedik C, Asian G, Arik S. Is presence of metabolic syndrome higher in patients with as thma. Acta Clin Belg. 2011 66(1): 49-52.
Ekerlyling L, Andersson A, Surdblad BM. Has the increase in the prevalence of asthma and respiratory symptoms reached a plateau in Stockholm, Sweden? Int J Tuberc Lung Disease 2010; 14: 764-771.
Albert KG, Eckel RU, Grundy SM. Harmonising the metabolic syndrome. Ciriculation 2009, 120: 1640-1645.
Suchita S, Sutapa S, Prakash Y S, Kumar M, Ahmad T, Sing V P et al. Asthma and metabolic syndrome in search of the interfaces. International Archives of Medicine 2012, 5(20).
Adeyeye OO, Ogem AO, Ogunleye OO, Brodie-Mens AT, Abolarinwa FF, Bamisile RT, et al. Understanding asthma and the metabolic syndrome. A Nigerian Report. International Archives of medicine 2012, 5 (5).
Beuther DA, Sutherlard ER. Overweight, obesity and incident Asthma. A meta-analysis of prospective epidermiologic studies. Am J Respir Crit Care Medicine 2007, 175 (7): 661. 6.
Uzunlulu M, Oguz A, Gedik C, asian G, Arik S. is prevalence of metabolic syndrome high in patients with asrhma? Acta Clin Belg 2011; 66(1): 49-52.
Brumpton BM, Carmago CA, Romunstad PR, Langhammer A, Chen Y. Metabolic syndrome and incidence of asthma in adults. The HUNT study. Eur Respir J 2013, 42 (6): 1495, 502.
Assad N, Qualis C, Smith L J, Argynchyn A, Thyagarajan B, Schuyler M et al. Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. The longitudinal study. Am J Respir Crit Care Med 2013, 88 (3): 319-26.
Formo E, Han YY, Muzumadar RH, Celedon JC. Insulin resistance, metabolic syndrome and lung function in US adolescent with and without asthma J allergy Immunol 2015, 136(2): 304-311.
Wats H, Wasch K, B. Kwisten A, Muller KC, Kretschmar, Meyer T, The metabolic syndrome in ph with chronic brunche and cipn: frequency associated consequences for systemic inflammation and physical inactivity. Chest 2009, 136 (4): 1039-46.
Fawn Yeh, Anne Dixon Susan Marian, Carl Schreter, Ying Zhang, Ihyle Best et al. Obesity in children is associated with reduced lung function in metabolic syndrome and diabetes. Diabetes Care 2011, 34 (10): 2300-2313.
Ford ES. The epidermiology of obesity and asthma. J Allergy Clin Immunol. 2005; Am Respir Crit Care Med. 2005; 115: 897-909; quiz 910.
Lee EJ, In KH, Ha Es, Hur, GY, Kang EH, Jung KU. Asthma-like symptoms are increased in the metabolic syndrome J Asthma 2009, 46 (4): 339-42.
Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA. The relationship of body mass index to asthma, chronic bronchitis, and emphysema. Chest 2002, 122(4): 1256-63.
Lin WY, Yao CA, Wang HC, Huang KC. Improved lung function is associated with obesity and metabolic syndrome in adult. Obesity (silver spring) 2006, 14(9): 1654-61.
Parkhales, Doucette S, Vandeemheen K, Bailet LP, Mdver RA, Fitzgerad JM, et al. A comparism of obesity and non-obese people with asthma: exploring an asthma-obesity interaction. Chest 2010 137(6): 1316-26.
Tai A, Volkmer R, Burton A. Association between asthma symptoms and obesity in preschool (4-5 year old) children. J Asthma 2009, 46 (4): 362-5.
Perez M G, Piedimonte G. Metabolic asthma: Is there a link between obesity, diabetes and asthma? Clin North Am 2014, 34 (4): 77-84.
Agrawal A, Prakash YS. Obesity, metabolic syndrome and airway diseases; a bioenergetic problems. Immunol Allergy Clin North Am 2014, 34: 785-796.
Shore SA, Johnston RA. Obesity and asthma. Pharmcol Ther. 2006, 110 (1): 83-102.
Shove Stephanie A. Obesity among hyper-responsiveness and inflammation. Journal of applied physiology.2010, 108(3): 735-743.
Jensen ME, Gibson PG, Collins CE, Wood LG. Air way and systemic inflammation in obese children with asthma. Eur Respir J. 2013, 42: 1012-1019.
Garmendia JV, Moreno D, Garcia AH, De Sanctis JB. Metabolic syndrome and asthma. Recent Pat Endocr metab Imune Drugs Discov. 2014, 8:60-66.
Dadom. P, Ghanim H, Monte, SV, Caruana JA, Green K, Abuaysheh S, Lohano T et al. Increase in the mediators of asthma in obesity and obesity with type 2 Diabetes: reduction with weight loss. Obesity (silver spring). 20114, 22: 356-362.
Lugogo NL, Bappanel D, Kraft M. Obesity, Metabolic dysregulation and oxidative stress in asthma. Biochim Biophys Acta. 2011, 1810: 1120-1126.
Husemoen LLN, Glumer C, Lau C, Pisinger C, Morch LS, Linneberg A. Association of obesity and insulin resistance with asthma and aeroallergen sensitization. “Diabetes Care 1991; 1463: 173-194.
Akpinar EE, Akpinar S, Ertek S, Saying E, Gulhan M. Systemic inflammation and metabolic syndrome in stable COPD patients. Tuberkuloz ve Toraks. 2012: 60(3): 230-237.
Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit care Med 2006; 174: 112-119.
Beuthes DA. Obesity and asthma. Parmacol ther 2006, 110: 83-102.
Rasmuen F, Hancox RJ, Nair P, Hansen HS, Siersted HC. Association between airway hyperresponsiveness, obesity and lipoprotein in a longitudinal cohort. Clin Respir J 2013; 7: 268-275.
Ma J, Xiao L, Knowles SB. Obesity, Insulin resistance and the presence of atopy and asthma in US adults. Allergy 2010; 65: 1455-1463.