Ethiopian National Tuberculosis Reference Laboratory Ten Year External Quality Assurance-Panel Test Performance Review
American Journal of Laboratory Medicine
Volume 1, Issue 2, September 2016, Pages: 5-8
Received: Sep. 11, 2015; Accepted: Aug. 20, 2016; Published: Sep. 7, 2016
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Authors
Mengistu Tadesse K., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Getahun M., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Kebede A., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Yaregal Z., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Meaza A., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Dagne Z., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Moga S., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Addise D., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Tesfaye E., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Yenew B., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Mollalign H., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Diriba G., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Girmachew F., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Dimssea D., National Tuberculosis Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Marondera B., FIND Diagnostics/Expand TB Project, EPHI, Addis Ababa, Ethiopia
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Abstract
The Objective of this review was to see the ten year EQA performance trend from 2005 till 2014 at Ethiopian national tuberculosis Reference laboratory. The finding shows that 81.3% and 11.2%of participation were ZN-AFB and of phenotypic DST respectively. The remaining participation was for LPA-PT with proportion of 4.6% and 2.3% for GeneXpert. Most of EQA-PT performance of NTRL scored above 80% and above 90% for Phenotypic DST of 1st and 2nd line Anti-TB drug. DST efficiency reveal that most tested drugs at NTRL were achieved acceptable performance and good agreement result compared to SRLN laboratory test with record data of above 90% for all 1st line and 2nd line drugs with the exception of Ethambutol. Over all TAT record were acceptable with the exception of phenotypic DST which is Critical TAT findings that ranges from 100 to 841 days from total 4 round 1ST and 2nd line DST -PT participation With the median TAT of 205 days. The most frequently committed error type were High false Negative, which accounts 3% contribution for total loss of PT score. The review finding shows there were some gaps on Critical TAT therefore a periodic review and evidence based corrective action has to be made in short time interval after feedback obtained since laboratory error will have devastating impact on clinical management of Patients and laboratory information.
Keywords
AFB-PT, NTRL, NICD, DST, EQA, TAT
To cite this article
Mengistu Tadesse K., Getahun M., Kebede A., Yaregal Z., Meaza A., Dagne Z., Moga S., Addise D., Tesfaye E., Yenew B., Mollalign H., Diriba G., Girmachew F., Dimssea D., Marondera B., Ethiopian National Tuberculosis Reference Laboratory Ten Year External Quality Assurance-Panel Test Performance Review, American Journal of Laboratory Medicine. Vol. 1, No. 2, 2016, pp. 5-8. doi: 10.11648/j.ajlm.20160102.11
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