Evaluation of Tigecycline Susceptibility in Multidrug-Resistant Bacteria at the University Hospital of Marrakech (Morocco)
American Journal of Laboratory Medicine
Volume 4, Issue 2, March 2019, Pages: 44-47
Received: Mar. 16, 2019; Accepted: Apr. 16, 2019; Published: May 17, 2019
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Authors
Zemrani Yassin, Laboratory of Medical Analysis, Microbiology Unit, University Hospital and Faculty of Medicine and Pharmacy, Cadi Ayad University, Marrakech, Morocco
Ahroui Yassine, Laboratory of Medical Analysis, Microbiology Unit, University Hospital and Faculty of Medicine and Pharmacy, Cadi Ayad University, Marrakech, Morocco
Ait Zirri Khadija, Laboratory of Medical Analysis, Microbiology Unit, University Hospital and Faculty of Medicine and Pharmacy, Cadi Ayad University, Marrakech, Morocco
Eddyb Saadia, Laboratory of Medical Analysis, Microbiology Unit, University Hospital and Faculty of Medicine and Pharmacy, Cadi Ayad University, Marrakech, Morocco
Soraa Nabila, Laboratory of Medical Analysis, Microbiology Unit, University Hospital and Faculty of Medicine and Pharmacy, Cadi Ayad University, Marrakech, Morocco
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Abstract
The phenomenon of bacterial resistance to antibiotics is a major public health problem. The prevalence of multidrug-resistant bacteria is rapidly increasing with heavy consequences in terms of morbidity and mortality and health care costs. Tigecycline is a new active glycylcycline on this type of germ and could be a therapeutic alternative for the management of these infections. The aim of this work is to evaluate the in vitro activity of Tigecycline against multidrug-resistant organisms isolated at Mohammed VI hospital in Marrakech. It is a descriptive prospective study of a series of 171 multidrug-resistant bacteria including 102 clinical isolates of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL) and 85 clinical isolates of multidrug-resistant Acinetobacter baumannii. The in vitro activity of Tigecycline was measured by the determination of the minimum inhibitory concentration (MIC) by diffusion method on agar medium using the strips "E-test" according to the recommendations of the CASFM. 71% of Acinetobacter baumannii isolates were sensitive to Tigecycline of with MIC ≤1mg / l, while 17.6% of tested strains had intermediate sensitivity to Tigecycline with a MIC between 1 and 2 mg / l, 11,4% were resistant with a MIC> 2 mg / l. ESBL enterobacterial strains were mostly (77,5%) with a MIC ≤ 1 mg / l. Intermediate sensitivity was found in 15.6% of the isolates with a MIC between 1 and 2 mg / l, however, resistance to Tigecycline was found in 6.8% of enterobacterial isolates with a MIC> 2 mg /l. Tigecycline is an interesting therapeutic option and may have an important role in the treatment of multidrug-resistant infections. Detection of the sensitivity status of Tigecycline is necessary to optimize its use and preserve this molecule in our therapeutic arsenal.
Keywords
Tigecycline, Multidrug-Resistant Bacteria, In Vitro Activity
To cite this article
Zemrani Yassin, Ahroui Yassine, Ait Zirri Khadija, Eddyb Saadia, Soraa Nabila, Evaluation of Tigecycline Susceptibility in Multidrug-Resistant Bacteria at the University Hospital of Marrakech (Morocco), American Journal of Laboratory Medicine. Vol. 4, No. 2, 2019, pp. 44-47. doi: 10.11648/j.ajlm.20190402.14
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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