American Journal of Laboratory Medicine
Volume 4, Issue 2, March 2019, Pages: 35-39
Received: Mar. 15, 2019;
Accepted: Apr. 22, 2019;
Published: May 9, 2019
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Sona Appukutty, Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Silvana Di Palma, Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Stephen Whitaker, Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Katie Wood, Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.
Silvana Di Palma,
Olfactory Neuroblastoma Presenting as a Submandibular Mass, American Journal of Laboratory Medicine.
Vol. 4, No. 2,
2019, pp. 35-39.
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