American Journal of Laboratory Medicine
Volume 4, Issue 1, January 2019, Pages: 11-18
Received: Dec. 12, 2018;
Accepted: Dec. 27, 2018;
Published: Mar. 25, 2019
Views 90 Downloads 21
Nabil Ahmad Bashir, Department of Physiology and Biochemistry and Department of Medical Laboratory Sciences, Faculty of Medicine, Balqa Applied University Medical School (Sabbatical) and Jordan University of Science and Technology, Irbid, Jordan
Adnan Ahmad Mohammad Bashir, Industrial Engineering Department, Abu Dhabi University and Hashemite University, Zarqa, Jordan
Hani Adnan Bashir, School of Medicine, Hashemite University, Zarqa, Jordan
The purpose of this study is to investigate the effect of vitamin D deficiency on lipid parameters; cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL). Serum level of vitamin D and the lipid parameters were determined in 127 subjects attending private community lab in eastern Amman province, using commercially available kits. Deficiency and insufficiency of vitamin D were 36.2%, 29.9%, respectively. Serum level of cholesterol, triglycerides, and LDL in deficient and insufficient vitamin D subjects were significantly increased, while HDL level was decreased, P-value <0.05. Serum levels of lipid profile and vitamin D in each of the control, insufficient , and deficient groups were all normally distributed due to the fact that P-value is greater than 0.05. Interval plot analysis and One-way ANOVA analysis revealed a significant effect of vitamin D insufficiency or deficiency on serum level of cholesterol, triglycerides, and LDL and increases the levels more than the double. Two samples T-test for every lipid parameter analysis related to subjects in the sufficient, insufficient and deficient vitamin D groups confirm our hypothesis on the effect of vitamin D deficiency on increasing the levels of cholesterol, triglycerides, and LDL and decreasing the level of HDL.
Nabil Ahmad Bashir,
Adnan Ahmad Mohammad Bashir,
Hani Adnan Bashir,
Effect of Vitamin D deficiency on Lipid Profile, American Journal of Laboratory Medicine.
Vol. 4, No. 1,
2019, pp. 11-18.
Richa Giri, Rohit Rai, Rajendra Kumar Verma, Shivendra Verma . Correlation between vitamin D and lipid profile in patients with ischemic stroke DOI: http://dx.doi.org/10.18203/2320-6012.ijrms, 2016.1805.
Pallavi M, Amarjeet S B: Diminished Levels of Vitamin D and Altered Lipid Profile DOI: https://dx.doi.org/10.18535/jmscr/v5i6.148
Zaher F, Sumay H, Muhammad B H, Safa , and Abdul A. Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? J Saudi Heart Assoc. 2015 Oct; 27(4): 264–271. Published online 2015 Feb 14. doi: 10.1016/j.jsha.2015.02.003. PMCID: PMC4614899, PMID: 26557744
Liyanage GC1, Lekamwasam S2, Weerarathna TP2, Liyanage CE3Diabetes Metab Syndr. 2017 Dec; 11 Suppl 2: S767-S770. doi: 10.1016/j.dsx.2017.05.013. Epub 2017 Jun 3. Effects of high-dose parenteral vitamin D therapy on lipid profile and blood pressure in patients with diabetic nephropathy: A randomized double-blind clinical trial.
Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol. 2013; 28(3): 205–221. doi: 10.1007/s10654-013-9790-2. [PubMed] [Cross Ref]
Daniel Mauss1, Marc N. Jarczok1, Kristina Hoffmann1, G. Neil Thomas1,2, Joachim E. Fischer1. Association of Vitamin D Levels with Type 2 Diabetes in Older Working Adults, International Journal of Medical Sciences, 2015; 12(5): 362-368. doi: 10.7150/ijms.10540.
Afzal S, Bojesen SE, Nordestgaard BG. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clin Chem. 2013; 59(2): 381–391. doi: 10.1373/clinchem.2012.193003. [PubMed] [Cross Ref]
Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 2012; 55(8): 2173–2182. doi: 10.1007/s00125-012-2544-y. [PubMed] [Cross Ref]
Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res. 2011; 50(4): 303–312. doi: 10.1016/j.plipres.2011.05.001. [PubMed] [Cross Ref]
Paul L , Marelise E , Natasjavan S, Mirjam O , Renatede J, Yvonne KP, and Suat S. Vitamin D and type 2 diabetes, The Journal of Steroid Biochemistry and Molecular Biology, Volume 173, October 2017, Pages 280-285
Jafari T, Faghihimani E, Feizi A, Iraj B, Javanmard SH, Esmaillzadeh A, Fallah AA, Askari G. Clin Nutr. 2016 Feb; 35(1): 67-76. doi: 10.1016/j.clnu.2015.02.014. Epub 2015 Mar 5. Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial.
Skaaby T, Thuesen BH, Linneberg A. Vitamin D, Cardiovascular Disease and Risk Factors. Adv Exp Med Biol. 2017; 996: 221-230. doi: 10.1007/978-3-319-56017-5_18.
Raposo L, Martins S, Ferreira D, Guimarães JT, Santos AC. Vitamin D, parathyroid hormone and metabolic syndrome . BMC Endocr Disord. 2017 Nov 17; 17(1): 71. doi: 10.1186/s12902-017-0221-3.
Jafari T, Fallah AA, Barani A. Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: A meta-analysis of randomized controlled trials Clin Nutr. 2016 Dec; 35(6): 1259-1268. doi: 0.1016/j.clnu.2016.03.001. Epub 2016 Mar 15.
Tamer G; Telci C O; Gungor K; Kartal I; Sagun HG,; Arik S,; Bozkurt CI; MutluHH. Effect of vitamin D status on lipid profile in premenopausal women: a cross-sectional study. Cardiovascular Endocrinology & Metabolism: June 2017 - Volume 6 - Issue 2 - p 86–91, doi: 10.1097/XCE.0000000000000124, DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161805
Monlezun D J., Camargo CA., Mullen JT. , Quraishi SA. Vitamin D Status and the Risk of Anemia in Community-Dwelling Adults: Results from the National Health and Nutrition Examination Survey 2001–2006, Medicine: December 2015 - Volume 94 - Issue 50 - p e1799, doi: 10.1097/MD.0000000000001799
Karhapää J. Pihlajamäki I. Pörsti G“Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias,” Journal of Internal Medicine, vol. 268, no. 6, pp. 604–610, 2010. View at Publisher · View at Google Scholar · View at Scopus.
Verena Schwetz, , Hubert Scharnagl, Tatjana Stojakovic, , Marlene Pandis, Martin R. Grübler, Nicolas Verheyen, Martin Gaksch, Armin Zittermann, Felix Aberer, Elisabeth Lerchbaum, Barbara Obermayer-Pietsch, Thomas R. Pieber, Winfried März, Andreas Tomaschitz, Stefan Pilz. Vitamin D supplementation and lipoprotein metabolism: A randomized controlled trial. Journal of clinical lipdology, May–June, 2018Volume 12, Issue 3, Pages 588–596.e4, DOI: https://doi.org/10.1016/j.jacl.2018.03.079.
Alkippi N, Marina T, Nikolaos M, Anargyros M, Anastassios P, and Michael K. Vitamin D in cardiovascular disease, doi: 10.21873/invivo.11338, In Vivo September-October 2018 vol. 32 no. 5 977-981.
Choi h s., Kim K. A., Lim C. Y. “Low serum vitamin D is associated with high risk of diabetes in Korean adults,” Journal of Nutrition, vol. 141, no. 8, pp. 1524–1528, 2011. View at Publisher · View at Google Scholar · View at Scopu
Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 2012; 97: 1953 - 61; http://dx.doi.org/10.1210/jc.2011-3187; PMID: 22442263.
García-Bailo B, Da Costa LA, Arora P, Karmali M, El-Sohemy A, Badawi A. Plasma vitamin D and biomarkers of cardiometabolic disease risk in adult Canadians, 2007-2009. Prev Chronic Dis 2013; 10: E91; http://dx.doi.org/10.5888/pcd10.120230; PMID: 23742939
Anania LC, Osborn JF, Ferraro F, Bonci E, Olivero E, Chiesa C. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol 2011; 165: 603 - 11; http://dx.doi.org/10.1530/EJE-11-0545; PMID: 21753070.
Mohammed S D, Association between Vitamin D deficiency and psoriasis: An exploratory study, Int J Health Sci (Qassim). 2018 Jan-Feb; 12(1): 33–09. PMCID: PMC5870311, PMID: 29623015.
Hajas A, Sandor J, Csathy L, Csipo I, Barath S, Paragh G, Seres I, Szegedi G, Shoenfeld Y, Bodolay E. Vitamin D insufficiency in a large MCTD population. Autoimmun Rev 2011; 10: 317 - 24; http://dx.doi.org/10.1016/j.autrev.2010.11.006; PMID: 21156217
Cigolini M., Iagulli MP, Miconi V., Galiotto M., Lombardi S., and Targher G., “Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients,” Diabetes Care, vol. 29, no. 3, pp. 722–724, 2006. View at Google Scholar · View at Scopus.
Asma MA, and Naser AA, Current Evidence on Vitamin D Deficiency and Metabolic Syndrome in Obese Children: What Does the Evidence from Saudi Arabia Tell Us? Children (Basel). 2018 Jan; 5(1): 11. Published online 2018 Jan 15. doi: 10.3390/children5010011, PMCID: PMC5789293, PMID: 29342981.
Choi HS., Kim KA., Lim CY. “Low serum vitamin D is associated with high risk of diabetes in Korean adults,” Journal of Nutrition, vol. 141, no. 8, pp. 1524–1528, 2011. View at Publisher · View at Google Scholar · View at Scopus.
Ahmadi F, Mirjafari SR, Khatami MR, Khazaeipour Z, Ranjbarnovin N. Relationship between serum parathyroid hormone levels and lipid profile in non-diabetic hemodialysis patients. Saudi J Kidney Dis Transpl 2012; 23: 1188-95.
Antonio JL, Jamerson RC, Maria LGR, Diego BCB. Vitamin D Deficiency and Cardiovascular Diseases, Int. J. Cardiovasc. Sci. vol.31 no.4 Rio de Janeiro July/Aug. 2018 Epub May 21, 2018, http://dx.doi.org/10.5935/2359-4802.20180025.