Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation
American Journal of Laboratory Medicine
Volume 3, Issue 1, January 2018, Pages: 6-10
Received: Sep. 23, 2017;
Accepted: Oct. 16, 2017;
Published: Dec. 14, 2017
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Mei-Min Shiu, Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Bo-Yu Huang, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Chien-Chi Liu, Department of Nursing, Hung Kuang University, Taichung, Taiwan
Chin-Sheng Liao, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Ming-Cheng Lin, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation, American Journal of Laboratory Medicine.
Vol. 3, No. 1,
2018, pp. 6-10.
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