Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation
American Journal of Laboratory Medicine
Volume 3, Issue 1, January 2018, Pages: 6-10
Received: Sep. 23, 2017; Accepted: Oct. 16, 2017; Published: Dec. 14, 2017
Views 2389      Downloads 126
Mei-Min Shiu, Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Bo-Yu Huang, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Chien-Chi Liu, Department of Nursing, Hung Kuang University, Taichung, Taiwan
Chin-Sheng Liao, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Ming-Cheng Lin, Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Article Tools
Follow on us
Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
Antrodia Camphorata, Lipid Peroxidation, Antioxidative Effect, Malondialdehyde
To cite this article
Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin, Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation, American Journal of Laboratory Medicine. Vol. 3, No. 1, 2018, pp. 6-10. doi: 10.11648/j.ajlm.20180301.12
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Shen, Y. C., Chou, C. J., Wang, Y. H., Chen, C. F., Chou, Y. C., & Lu, M. K. (2004). Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiol Lett, 231 (1), 137-143.
Lee, J. J., Hsu, W. H., Yen, T. L., Chang, N. C., Luo, Y. J., Hsiao, G., & Sheu, J. R. (2011). Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats. J Ethnopharmacol, 134 (3), 824-830.
Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001). Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacological reviews, 53 (1), 135-159.
Hsiao, G., Shen, M.-Y., Lin, K.-H., Lan, M.-H., Wu, L.-Y., Chou, D.-S., Sheu, J.-R. (2003). Antioxidative and hepatoprotective effects of Antrodia camphorata extract. Journal of agricultural and food chemistry, 51 (11), 3302-3308.
Cheng, P.-C., Hsu, C.-Y., Chen, C.-C., & Lee, K.-M. (2008). In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicology and Applied Pharmacology, 227 (2), 291-298.
Hseu, Y.-C., Yang, H.-L., Lai, Y.-C., Lin, J.-G., Chen, G.-W., & Chang, Y.-H. (2004). Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutrition and Cancer, 48 (2), 189-197.
Song, T.-Y., & Yen, G.-C. (2003). Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. Journal of agricultural and food chemistry, 51 (6), 1571-1577.
Hsu, Y.-L., Kuo, Y.-C., Kuo, P.-L., Ng, L.-T., Kuo, Y.-H., & Lin, C.-C. (2005). Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer letters, 221 (1), 77-89.
Malik, Z. A., Singh, M., & Sharma, P. (2011). Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. Journal of Ethnopharmacology, 133 (2), 729-734.
Lee, Y.-M., Chang, C.-Y., Yen, T.-L., Geraldine, P., Lan, C.-C., Sheu, J.-R., & Lee, J.-J. (2014). Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence. The Scientific World Journal, 2014.
Hsiao, G., Lin, K. H., Chang, Y., Chen, T. L., Tzu, N. H., Chou, D. S., & Sheu, J. R. (2005). Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. Arteriosclerosis, thrombosis, and vascular biology, 25 (9), 1998-2004.
Huang, F.-P., Xi, G., Keep, R. F., Hua, Y., Nemoianu, A., & Hoff, J. T. (2002). Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. Journal of neurosurgery, 96 (2), 287-293.
Nazıroğlu, M., Kutluhan, S., Uğuz, A. C., Çelik, Ö., Bal, R., & Butterworth, P. J. (2009). Topiramate and vitamin E modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. Journal of Membrane Biology, 229 (3), 131-140.
Limón-Pacheco, J., & Gonsebatt, M. E. (2009). The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 674 (1), 137-147.
Sun, A. Y., Wang, Q., Simonyi, A., & Sun, G. Y. (2008). Botanical phenolics and brain health. Neuromolecular medicine, 10 (4), 259-274.
Özcelik, D., Uzun, H., & Nazıroglu, M. (2012). N-acetylcysteine attenuates copper overload-induced oxidative injury in brain of rat. Biological trace element research, 147 (1-3), 292-298.
Meneghini, R. (1997). Iron homeostasis, oxidative stress, and DNA damage. Free Radical Biology and Medicine, 23 (5), 783-792.
Fang, K.-M., Cheng, F.-C., Huang, Y.-L., Chung, S.-Y., Jian, Z.-Y., & Lin, M.-C. (2013). Trace element, antioxidant activity, and lipid peroxidation levels in brain cortex of gerbils after cerebral ischemic injury. Biological trace element research, 152 (1), 66-74.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186