Haematological Parameters in Pregnant Women Attended Antenatal Care at Sabratha Teaching Hospital in Northwest, Libya
American Journal of Laboratory Medicine
Volume 2, Issue 4, July 2017, Pages: 60-68
Received: Feb. 18, 2017; Accepted: Mar. 10, 2017; Published: Oct. 23, 2017
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Authors
Azab Elsayed Azab, Department of Zoology, Faculty of Science, Alejelat Zawia University, Alejelat, Libya
Mohamed Omar Albasha, Department of Zoology, Faculty of Science, Alejelat Zawia University, Alejelat, Libya
Sara Yosef Elhemady, Department of Medical Engineering, School of Applied and Engineering Sciences, Academy of Graduate Studies, Tripoli, Libya
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Abstract
The aim of this study was to evaluate the values of hematological parameters at different trimesters of pregnancy in pregnant women who attended antenatal care at Sabratha Teaching Hospital, Northwest Libya. This cross-sectional survey included consecutive pregnant women who attended the obstetrical department in Sabratha Teaching Hospital for prenatal booking. This study was carried out over period of 6 month from April 2016 to September 2016. The study involved 120 pregnant women as the study group and 40 non-pregnant women as control. The study pregnant women were between the ages of 18 to 45 years. 5 ml of venous blood samples were taken from each pregnant woman in K3-EDTA tubes for the haematological examinations. The analysis of haematological indices was done using automated hematological analyzer. The obtained results showed that the mean age of pregnant women was 30 years ± 5.8 SD, 48.4% of pregnant women were between 21-30 years old, 40.8% were at age between 31-40 years. The most prevalent blood group in pregnant women was group O, 47.5%; followed by blood group A, 28.3%; blood group B, 17.5% and blood group AB, 6.7%. 15.8% of the pregnant women were observed to lack Rh antigen in their blood. Highly significance decrease in Hb, Hct, MCH, MCHC, lymphocytes%, RBCs and blood platelets count and significant decrease in MCV as compared with non pregnant women. On the other hand, highly significance increased in WBCs count, and neutrophils % of pregnant women compared with non pregnant women. A progressive decline in Hb concentration and haematocrite values from the first to third trimester was observed. The mean corpuscular volume was significantly decreased in the second trimester. The values of MCH showed highly significant decrease in the second and third trimester, and MCHC decreased significantly in the first trimester. WBC count and neutrophils % showed highly significant increase from the first to the third trimester. Lymphocytes % were highly significant decreased from the first to the third trimester. Mixed percentage of leukocytes (eosinophil, basophil and monocytes) decreased significantly in the third trimester. Platelets count exhibited a highly significant decrease in the second and third trimesters, and a significantly decrease in the first trimester. It can be concluded that a significant changes in the haematological parameters at different trimesters of pregnancy in pregnant women. So it is essential to monitor and manage these parameters during pregnancy.
Keywords
Haematological Changes, Pregnant Women, Trimesters of Pregnancy, Blood Groups
To cite this article
Azab Elsayed Azab, Mohamed Omar Albasha, Sara Yosef Elhemady, Haematological Parameters in Pregnant Women Attended Antenatal Care at Sabratha Teaching Hospital in Northwest, Libya, American Journal of Laboratory Medicine. Vol. 2, No. 4, 2017, pp. 60-68. doi: 10.11648/j.ajlm.20170204.14
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Mohamed A. O., Hamza K. M., Babker A. M. A. (2016). Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. Int. J. Med. Sci. Public Health, 5: 525-528.
[2]
Purohit G., Shah T., and Harsoda J. M. (2015). Hematological profile of normal pregnant women in Western India. Sch. J. App. Med. Sci., 3 (6A): 2195-2199.
[3]
Chandra S., Tripathi K., Mishra S., Amzarul M., and Vaish A. (2012). Physiological changes in hematological parameters during pregnancy. Indian J. Hematol. Blood Transfus., 28 (3): 144–146.
[4]
Akinlaja O. (2016). Hematological changes in pregnancy - the preparation for intrapartum blood loss. Obstet. Gynecol. Int. J., 4 (3): 00109.
[5]
Akinbami A. A., Ajibola S. O., Rabiu K. A., Adewunmi A. A., Dosunmu A. O., Adediran A., Osunkalu V. O., Osikomaiya B. I., and Ismail K. A. (2013). Hematological profile of normal pregnant women in Lagos, Nigeria. Inter. J. Women Health, 5: 227- 232.
[6]
Stevens G., Finucane M., De-Regil L., Paciorek C., Flaxman S., Branca F. et al. (2013). Nutrition impact model study group (Anaemia). Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: A systematic analysis of population-representative data. Lancet Glob Health., 1: 16-25.
[7]
Jiji D. B. and Rajagopal K. (2014). A study to assess the knowledge and risk factors of anaemia among the pregnant women attending selected health care facilities in Sebha, Libya. J. Sci., 4 (1): 19-22.
[8]
Abbassi-Ghanavati M., Greer L. G., and Cunningham F. G. (2006). Pregnancy and laboratory studies: a reference table for clinicians. Obstet. Gynecol., 114 (6): 1326–1331.
[9]
Boehlen F., Hohlfeld P., Extermann P., Perneger T. V., and de Moerloose P. (2000). Platelet count at term pregnancy: A reappraisal of the threshold. Obstet. Gynecol., 95 (1): 29–33.
[10]
Jensen J. D., Wiedmeier S. E., Henry E., Silver R. M., and Christensen R. D. (2011). Linking maternal platelet counts with neonatal platelet counts and outcomes using the data repositories of a multihospital health care system. Am. J. Perinatol., 28 (8): 597-604.
[11]
Onwukeme K. E., and Uguru V. E. (1990). Haematological values in pregnancy in Jos. W Afr. J. Med., 9 (2): 70–75.
[12]
Patel PA, Patel SP, Shah JV, et al. (2012). Frequency and distribution of blood groups in blood donors in western Ahmadabad – A hospital based study. National J Med Res, 2 (2): 202-206.
[13]
Elzahaf R. A., and Omar M. (2016). Prevalence of anaemia among pregnant women in Derna city, Libya. Int. J. Community Med. Public Health, 3 (7): 1915-1920.
[14]
Melku M., and Agmas A. (2015). Maternal anemia during pregnancy in Bahirdar Town, Northwestern Ethiopia: A facility-based retrospective study. Appl. Med. Res., 1 (1): 2-7.
[15]
Haileamlak A., Muluneh A. T., Alemseged F, et al. (2012). Hematoimmunological Profile At Gilgel Gibe Field Research Center, Southwest Ethiopia. Ethiop J. Health Sci., 22: 39-50.
[16]
Alemu M., Abrha G., Bugssa G., and Tedla K. (2014). Frequency of ABO and Rh (D) blood groups and hemoglobin threshold among pregnant women in family guidance association, Mekelle model clinic, North Ethiopia. Inte. J. Pharm. Sci. Res., 5 (12): 892-895.
[17]
Bhalti F. A., and Amin (1996). Spectrum of ABO and D blood groups of donors at Rawalpindi/ Islamabad. Pakistan J. Pathol., 7 (2): 26-28.
[18]
Pramanik T., and Pramanik S. (2000). Distribution of ABO and Rh blood groups in Nepalese students: a report. Eastern Mediterranean Health J., 6 (1): 156-158.
[19]
Chavhan A., Pawar S., and Baig M. M. (2010). Allelic frequency of ABO and Rh D blood group among the Banjara backward caste of Yavatmal district, Maharashtra, India. Nature Precedings: hdl:10101/npre.2010.5482.1.
[20]
Kibaya R. S., Bautista C. T., Sawe F. K., et al.(2008). Reference ranges for the clinical laboratory derived from a rural population in Kericho, Kenya. PLoS One, 3 (10): 3327. DOI: 10.1371/journal.pone.0003327.
[21]
Omotade O. O., Adeyemo A. A, Kayode CM, et al.(1999). Gene frequencies of ABO and Rh (D) blood group alleles in a healthy infant population in Ibadan, Nigeria. West Afr. J. Med., 18: 294-297.
[22]
Khojasteh F., Arbabisarjou A., Boryri T., Safarzadeh A., and Pourkahkhaei M. (2016). The relationship between maternal employment status and pregnancy outcomes. Global J. Health Sci., 8 (9): 37-43.
[23]
Shah A., Patel N. D., and Shah M. H. (2012). Hematological parameters in anemic pregnant women attending the antenatal clinic of rural teaching hospital. Innovative J. Med. Health Sc., 2 (5): 70-73.
[24]
Akingbola T., Adewole I. F., Adesina O. A., Afolabi K. A., Fehintola F. A., Bamgboye E. A., Aken'ova Y. A., Shokunbi W. A., Anwo J. A., and Nwegbu M. M. (2006). Haematological Profile of healthy pregnant women in Ibadan, south western Nigeria. J. Obstet. Gynaecol., 26 (8): 763- 769.
[25]
Barriga C., Rodriguez A. B., and Orega E. (1994). Increased phagocytic activity of polymorphonuclear leucocytes during pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol., 57 (1): 43-46.
[26]
Ajzenberg N., Dreyfus M., Kaplan C., Yvart J., Weill B., and Tchernia G. (1998). Pregnancy-associated thrombocytopenia revisited: assessment and follow-up of 50 cases. Blood, 92 (12): 4573-4580.
[27]
Ramsay M. (2010). Normal hematological changes during pregnancy and the puerperium. In: Pavord S, Hunt B (eds) The obstetric hematology manual. Cambridge University Press, Cambridge, pp: 1–11.
[28]
Wulsa N., Soren G., Pathapati R. M., and Buchineni M.(2015). Cardiopulmonary and hematological parameters in pregnancy. IAIM., 2 (12): 1-6.
[29]
Salawu L., and Durosinmi M. (2000). Erythrocyte rate and plasma viscosity in health and disease. J. National Association Resid. Doctors Nigeria, 10 (1): 11-3.
[30]
Imoru M., and Emeribe A. (2009). Haemorrheologic and fibrinolytic activities in pregnant women: Influence of gestational age and parity. African J Biotechnol., 8 (23): 6641-6644.
[31]
Oke O. T., Awofadeju S. O., and Oyedeji S. O. (2011). Haemorheological profiles in different trimesters among pregnant women in South West Nigeria. Pak. J. Physiol., 7 (2): 17-19.
[32]
Crocker I. P., Baker P. N., and Fletcher J. (2000). Neutrophil function in pregnancy and rheumatoid arthritis. Ann. Rheumat. Dis. 59: 555–564.
[33]
Fleming A. F. (1975). Hematological changes in pregnancy. Clin. Obstet. Gynecol. 2: 269-283.
[34]
Milhorat A. T., Small S. M., and Diethelm O. (1942). Leukocytosis during various emotional states. Arch Neurol. Psych., 47 (5): 779-792.
[35]
Kuvin S. F., and Brecher G. (1962). Differential neutrophil counts in pregnancy. N. Engl. J. Med., 266: 877-878.
[36]
Gatti L., Tinconi P. M., Guarneri D., Bertuijessi C., Ossola M. W., Bosco P., Gianotti G. (1994). Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: A longitudinal study. Internat J. Clin. Lab. Res., 24 (4): 217–219.
[37]
Konijnenberg A., Stokkers E., and van der Post J. (1997). Extensive platelet activation in preeclampsia compared with normal pregnancy: Enhanced expression of cell adhesion molecules. Am. J. Obstet. Gynecol., 176 (2): 461- 469.
[38]
Jessica M., Badger F., Hseih C. C., Troisi R., Lagiou P., and Polischman N. (2007). Plasma volume expansion in pregnancy: Implications for biomarkers in population studies. Cancer Epidemiol. Biomarkers 16: 1720 – 1723.
[39]
Karalis L., Nadan S., and Yemen E. A. (2005). Platelet activation in pregnancy induced hypertension. Thromb Res., 116 (5): 377-383.
[40]
Kline A. J., Williams G. W., and Hernandez-Nino J. (2005). D-Dimer concentration in normal pregnancy: new diagnostic thresholds are needed. Clin. Chem., 51 (5): 825-829.
[41]
Edlestam G., Lowbeer C., Kral G. et al (2001). New reference values for routine blood samples and human neutrophilic lipocalin during third trimester pregnancy. Scand J. Clin. Lab. Inv., 61: 583-592.
[42]
Ballem P. J. (1988). Hematological problems of pregnancy. Can. Fam. Physician., 34: 2531–2537.
[43]
McCrae KR. (2003). Thrombocytopenia in pregnancy: differential diagnosis, pathogenesis and management. Blood Rev., 17: 7-14.
[44]
Tsunoda T, Ohkuchi A, Izumi A, et al. (2002). Antithrombin III activity and platelet count are more likely to decrease in twin pregnancies than in singleton pregnancies. Acta Obstet. Gynecol. Scand., 81 (9): 840–845.
[45]
Fay R. A., Hughes A. O., Farron N. T. (1983). Platelets in pregnancy: hyperdestruction in pregnancy. Obstet. Gynecol., 61 (2): 238-240.
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