Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System
International Journal of Ophthalmology & Visual Science
Volume 2, Issue 4, November 2017, Pages: 98-105
Received: Mar. 24, 2017; Accepted: Apr. 22, 2017; Published: Sep. 21, 2017
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Varsha Gharge, Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education & Research, Shivaji University, Kolhapur, India
Pravin Pawar, Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education & Research, Shivaji University, Kolhapur, India
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A common diseased condition includes eye infections like conductivities and corneal disorder such as glaucoma etc. Some of the typical classes of drugs used for the ocular delivery are miotics, mydriatics/cycloplegics, anti-inflammatory, anti-infective, surgical adjuvant and diagnostics. This review presents an outline of the prospective of chitosan-based nanomedicine for the treatment of ocular infection for improving the corneal residence time and in vitro bioavailability. In addition, its minimum toxicity and good ocular tolerance, chitosan exhibits constructive biological behavior, like bioadhesion and good permeability with optimum physiochemical characteristics, which make it a unique biocompatible material for the ophthalmic application. The review summarizes the application of chitosan based nanomedicine such as nanoparticles, solid lipid nanoparticles, nanosuspention, nanosponge and nanogels for the treatment of ocular diseases. The results reported provide evidence of the potential of chitosan being natural polymers for enhancing therapeutics effect of drugs.
Chitosan Nanoparticles, Nanomedicine, Corneal Residence Time, in Vitro Bioavailability
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Varsha Gharge, Pravin Pawar, Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System, International Journal of Ophthalmology & Visual Science. Vol. 2, No. 4, 2017, pp. 98-105. doi: 10.11648/j.ijovs.20170204.14
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