Synthesis, Characterization and Antimicrobial Properties of Some 1,3,4-Thiadiazolines
American Journal of Applied Chemistry
Volume 6, Issue 2, April 2018, Pages: 64-70
Received: Apr. 13, 2018; Accepted: Apr. 26, 2018; Published: May 18, 2018
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Authors
Houssou Raymond Fatondji, Faculty of Sciences and Technics (FAST), University of Abomey-Calavi (UAC), Cotonou, Benin
Salomé Kpoviessi, Faculty of Sciences and Technics (FAST), University of Abomey-Calavi (UAC), Cotonou, Benin
Fernand Gbaguidi, Beninese Center for Scientific and Technical Research (CBRST), Oganla, Porto-Novo
Kamirou Chabi Sika, Faculty of Sciences and Technics (FAST), University of Abomey-Calavi (UAC), Abomey, Calavi, Benin
Joachim Gbenou, Beninese Center for Scientific and Technical Research (CBRST), Oganla, Porto-Novo
Georges Coffi Accrombessi, Faculty of Sciences and Technics (FAST), University of Abomey-Calavi (UAC), Cotonou, Benin
Mansourou Moudachirou, Beninese Center for Scientific and Technical Research (CBRST), Oganla, Porto-Novo
Jacques Poupaert, School of Pharmacy, Université Catholique de Louvain (UCL), Brussels, Belgium
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Abstract
Through The literature, there is little information about the antibacterial activity of 1,3,4-thiadiazoles. In order to verify if drugs based on this family of compounds could constitute an alternative to the antibiotics usually used in the antimicrobial fight, the aim of this work was to synthesize, to confirm the structures and then to test some 1,3,4-thiadiazolines for their antimicrobial activity against microbes. Twelve 1,3,4- thiadiazolines were synthesized with yields going from 27 to 95%. The products purity was confirmed by mass spectrometry coupled with high-performance liquid chromatography (LC/MS) and there were characterized using spectrometry IR, NMR 1H and 13C (nuclear magnetic resonance). The synthesized compounds were tested on strains of Escherichia coli ATCC 25922 and Salmonella typhimurium R 30951401 according to the macro-dilution method in liquid environment for a comparison of their antibacterial activity. Thiadiazoline 1 has been shown to be more active than other products. The most antibacterial thiadiazolines are those having para-electro attractor groups and also alkyl groups at R2. It could be a good drug candidate against these microbes.
Keywords
1,3,4-Thiadiazolines, Spectrometric Confirmation, Antimicrobial Properties
To cite this article
Houssou Raymond Fatondji, Salomé Kpoviessi, Fernand Gbaguidi, Kamirou Chabi Sika, Joachim Gbenou, Georges Coffi Accrombessi, Mansourou Moudachirou, Jacques Poupaert, Synthesis, Characterization and Antimicrobial Properties of Some 1,3,4-Thiadiazolines, American Journal of Applied Chemistry. Vol. 6, No. 2, 2018, pp. 64-70. doi: 10.11648/j.ajac.20180602.15
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Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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