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The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives
American Journal of Applied Chemistry
Volume 3, Issue 2, April 2015, Pages: 77-82
Received: Mar. 20, 2015; Accepted: Mar. 31, 2015; Published: Apr. 9, 2015
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Fernanda Andrade Mendonça, Departamento de Química, CCET / Universidade Federal de Viçosa, 36570-900, Viçosa, MG, Brasil
Geraldo José da Silva Junior, Departamento de Fitopatologia, CCA / Universidade Federal de Viçosa, 36570-900, Viçosa, MG, Brasil
José Roberto da Silveira Maia, Departamento de Química, CCET / Universidade Federal de Viçosa, 36570-900, Viçosa, MG, Brasil
Onkar Dev Dhingra, Departamento de Fitopatologia, CCA / Universidade Federal de Viçosa, 36570-900, Viçosa, MG, Brasil
Rosimeire Coura Barcelos, Departamento de Química, CCET / Universidade Federal de Viçosa, 36570-900, Viçosa, MG, Brasil
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High productivity of agriculture goods is closely associated with the use of fungicides to reduce losses caused by the fungal plant diseases. However, appearance of resistant population of pathogens to several commercial fungicides is a common phenomenon that requires control. There is, therefore, need for developing novel fungicide compounds that are environmentally safe with low toxicity to wild life and humans. In this study novel organotin(IV) derivatives of bis(pyrimidin-2-ylthio)methane (ptm), bis(pyrimidin-2-ylthio)ethane (pte) and bis(pyrimidin-2-ylthio)hexane (pth) were tested against phytopathogens to evaluate their activity as potential fungicides. The bis(pyrimidin-2-ylthio)alkanes were not active in contrast with the organotin(IV) derivatives. The 5-coordinate triphenyltin(IV) derivatives were the most active compounds in a wide range of concentration. This study shows that the microorganisms were susceptible to the acid character of the organotin(IV) precursors.
Antifungal, Organotin, Bis(Pyrimidin-2-Ylthio)Alkanes, Storage Fungus, Fungicide, Phytopathogens
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Fernanda Andrade Mendonça, Geraldo José da Silva Junior, José Roberto da Silveira Maia, Onkar Dev Dhingra, Rosimeire Coura Barcelos, The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives, American Journal of Applied Chemistry. Vol. 3, No. 2, 2015, pp. 77-82. doi: 10.11648/j.ajac.20150302.17
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