Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode
Science Journal of Analytical Chemistry
Volume 7, Issue 5, September 2019, Pages: 92-97
Received: Jul. 1, 2019; Accepted: Aug. 12, 2019; Published: Nov. 25, 2019
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Jayant Ira Gowda, Post Graduate Department of Studies in Chemistry, Parappa Channappa Jabin Science College, Hubballi, Karnataka, India
Rohini Manohar Hanabaratti, Department of Chemistry, Karnatak Science College, Dharwad, Karnataka, India
Sharanappa Thotappa Nandibewoor, Post Graduate Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, India
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Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
Tripelennamine Hydrochloride, Glassy Carbon Electrode, Detection Limit, Calibration Plot
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Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor, Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode, Science Journal of Analytical Chemistry. Vol. 7, No. 5, 2019, pp. 92-97. doi: 10.11648/j.sjac.20190705.11
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