Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds
American Journal of BioScience
Volume 3, Issue 2-1, April 2015, Pages: 12-18
Received: Jan. 23, 2015; Accepted: Jan. 23, 2015; Published: Feb. 27, 2015
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Authors
Majidul Haque, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Mst. Marium Begum, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Moynul Hasan, Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh
A. F. M. Towheedur Rahman, Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh
Md. Iftekhar Hussain, Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh
Mohammad Mizanur Rahman, Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh
Md. Hazrat Ali, Department of Pharmacy, International Islamic University, Chittagong-4203, Bangladesh
Md. Ashraful Islam, Department of Biomedical Imaging, Faculty of Bioscience, Abo Akademi University, Turku, Finland
Md. Zakir Sultan, Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000, Bangladesh
Md. Reyad-ul- Ferdous, Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh
Choudhury Mahmood Hasan, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
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Abstract
Syzygium jambos (L.) Alstone belonging to the Myrtaceae family have been investigated for isolation of their secondary metabolites and evaluation of their biological activities. A total of three compounds have been isolated. The isolated compounds were identified by extensive analysis of their high resolution 1H-NMR spectroscopic data.The dried stem barks of Syzygium jambos was extracted with methanol. The concentrated methanolic extract was then partitioned with vacuum liquid chromatography. The first investigation was conducted with the VLC fraction-6 afforded one pentacyclic triterpenes (SJ-61), VLC fraction-9 afforded a sitosterol (SJ-92) and VLC fraction-16 afforded a triterpene 3-nor-2,3-fridelan derivative (SJ-184). In the brine shrimp lethality bioassay, The LC50 values were found to be 6.97, 18.07, 64.943, 247.596 and 12.75mg/ml for crude methanolic extract, carbon tetrachloride, chloroform and n-hexane soluble fractions of methanolic extract of Syzygium jambos respectively representing methanolic extract fraction as highly cytotoxic.
Keywords
Medicinal Plant, Extraction, Isolation, Characterization, Cytotoxicity, Biological Activity
To cite this article
Majidul Haque, Mst. Marium Begum, Moynul Hasan, A. F. M. Towheedur Rahman, Md. Iftekhar Hussain, Mohammad Mizanur Rahman, Md. Hazrat Ali, Md. Ashraful Islam, Md. Zakir Sultan, Md. Reyad-ul- Ferdous, Choudhury Mahmood Hasan, Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds, American Journal of BioScience. Special Issue: Pharmacological and Phytochemicals Investigation. Vol. 3, No. 2-1, 2015, pp. 12-18. doi: 10.11648/j.ajbio.s.2015030201.13
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