Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock
American Journal of BioScience
Volume 3, Issue 4, July 2015, Pages: 133-140
Received: May 31, 2015; Accepted: Jun. 14, 2015; Published: Jul. 1, 2015
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Galina Fedorovna Leskova, Laboratory of nanopathology, nanotoxicology and biomedical nanotechnologies, Institute of General Pathology und Pathophysiology, Moscow, Russia
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Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy during HS. Stabilizing the PL composition of the neuronal membranes may become one of the most important treatment methods for shock-induced disorders of brain functions.
Phospholipids, Synaptic Membranes, Hemorrhagic Shock
To cite this article
Galina Fedorovna Leskova, Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock, American Journal of BioScience. Vol. 3, No. 4, 2015, pp. 133-140. doi: 10.11648/j.ajbio.20150304.13
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