Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats
American Journal of BioScience
Volume 1, Issue 1, May 2013, Pages: 11-15
Received: May 24, 2013; Published: Jun. 20, 2013
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Author
Oyetunji Timothy Kolawole, Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
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Abstract
Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.
Keywords
Monosodium Glutamate, Toxicity, Body Weight, Food Additive, Enzymes
To cite this article
Oyetunji Timothy Kolawole, Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats, American Journal of BioScience. Vol. 1, No. 1, 2013, pp. 11-15. doi: 10.11648/j.ajbio.20130101.13
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