Please enter verification code
Using Soursop Extracts for Natural Gout Treatment
American Journal of Bioscience and Bioengineering
Volume 3, Issue 5, October 2015, Pages: 37-39
Received: Jul. 27, 2015; Accepted: Aug. 5, 2015; Published: Sep. 17, 2015
Views 4920      Downloads 326
Mufeed Jalil Ewadh, Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq
Maha Fadhil Smaism, Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq
Ali Mohammed Jawad, Ministry of Science and Technology, Baghdad, Iraq
Samr Mkhlof, Tishreen University, Faculty of Medicine, Lattakia, Syria
Osama Muzahim Aljubouri, Babylon Health Office, Merjan Taching Hospital, Diabetology Center Medical Laboratory, Babylon, Iraq
Muna Mufeed Ewadh, Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq
Article Tools
Follow on us
Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.
Soursop, Gout, Xanthine Oxidase, Trace Elements
To cite this article
Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, Muna Mufeed Ewadh, Using Soursop Extracts for Natural Gout Treatment, American Journal of Bioscience and Bioengineering. Vol. 3, No. 5, 2015, pp. 37-39. doi: 10.11648/
Arromede, E., Michet, C. J., Crowson, C. S., O’ Fallon, W. M., and Gabriel S.E. Epidemiology of gout: is the incidence rising? J. Rheumatol.; 29, 2403-2406. (2002)
Kramer, HM., and Curhan, G. The association between gout and nephrolithiasis. Am. J. Kid. Dis.; 40, 37–42. (2002)
Lin, K. C, Lin, H. Y, and Chou, P. The interaction between uric acidlevel and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J. Rheumatol.; 27, 1501–1505. (2000)
Kong, L. D, Cai, Y., Huang, W. W, Cheng, C. H. K., and Tan, R.X. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J. Ethnopharmacol.; 73, 199-207. (2000)
Abdulsamie, H. Altaee., Mufeed J. Ewadh., Haider K. Zaidan Hormonal contents of two types of Black seed (nigella sativa) oil: comparative study. Medical Journal of Babylon 3 (1-2),17-22,(2006)
Ganesh N., Sharma S. K., Dubey S. N., and Sanadya J., Phytochemical screening and estimation of total phenolic content in Aegle marmelos seed. International Journal of pharmaceutical and clinical research; 3 (2):27-29. (2011)
Iswantini, D., N., Darusman, L. K. and T. Inhibition kinetic of Apium graveolen L. ethanol extract and its fraction on the activity of xanthine oxidase and its active compound. (2012)
Rasero, F. S.: Atomic Absorption Spectrophotometric Method for Determination of Water-Soluble Copper in Water-Insoluble Copper Fungicides: CIPAC Collaborative Study. Comparison with Bathocuproine Method. J. Assoc. Off. Anal. Chem., 64: 75-78.( 1981)
Intisar R. A Study of some Natural products as inhibitors of Xanthine Oxidase Activity. M. Sc thesis, Babylon University, College of medicine, Clinical biochemistry Dept. IRAQ (2014)
Umamaheswari, M., Asok Kumar, K., Somasundaram, A., Sivashanmugam, T., Subhadradevi, V. and Ravi, T. K. Xanthine oxidase inhibitory activity of some Indian medicinal plants. Journal of Ethnopharmacology 109 (3): 547-551. (2007).
Bondet, V., Brand-Williams, W., and Berset, C. Kinetic and mechanisms of antioxidant activity using DPPF free radical method. Lebensmittel-Wissenschaft&, 609-615. (1997)
Costantino, L., Albasini, A., Rastelli, G., and Benvenuti, S. Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase. Planta. Med.; 58, 342-344.(1992)
Cancer treatment center of America, May 30, (2013).
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186