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Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years
American Journal of Bioscience and Bioengineering
Volume 1, Issue 4, August 2013, Pages: 49-54
Received: Jun. 18, 2013; Published: Aug. 20, 2013
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Authors
David A. Areshidze, Center of Cell Biology and Applied Biotechnology, Moscow State Regional University, Moscow, Russian Federation
Lyudmila D. Timchenko, North Caucasian federal university, Stavropol, Russian Federation
Maria A. Кozlova, Center of Cell Biology and Applied Biotechnology, Moscow State Regional University, Moscow, Russian Federation
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Abstract
Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)
Keywords
Liver, Hydrolizate, Hepatotoxicity, Hepatocyte, Chlorophytum Comosum (L.)
To cite this article
David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova, Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years, American Journal of Bioscience and Bioengineering. Vol. 1, No. 4, 2013, pp. 49-54. doi: 10.11648/j.bio.20130104.11
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