Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010
Advances in Bioscience and Bioengineering
Volume 4, Issue 5, October 2016, Pages: 51-58
Received: Aug. 25, 2016;
Accepted: Sep. 26, 2016;
Published: Oct. 15, 2016
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Tingting Xu, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
Weixia Wang, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
Songya Lyu, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.
Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010, Advances in Bioscience and Bioengineering.
Vol. 4, No. 5,
2016, pp. 51-58.
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