The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence
Advances in Bioscience and Bioengineering
Volume 2, Issue 1, February 2014, Pages: 1-7
Received: Dec. 31, 2013;
Published: Feb. 20, 2014
Views 3298 Downloads 181
Bashir Mohammed Abubakar, Department of Biological Sciences, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria
Jibrin Ndejiko Mohammed, Department of Microbiology, Ibrahim Badamasi Babangida University Lapai, P.M.B 011, Niger, Nigeria
Abdulrahman Idris, Department of Microbiology, Kaduna State University, P.M.B. 2339, Kaduna, Nigeria
Hamzat Ibiyeye Tijani, Faculty of Bioscience & Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor-bahru, Malaysia
Saidu Haruna, Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
Yusuf Hindatu, Department of Biochemistry, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria
Mohammed Sulaiman, Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.
Bashir Mohammed Abubakar,
Jibrin Ndejiko Mohammed,
Hamzat Ibiyeye Tijani,
The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence, Advances in Bioscience and Bioengineering.
Vol. 2, No. 1,
2014, pp. 1-7.
Wang, L., J. Li, J.C. March, J.J. Valdes, and W.E. Bentley, luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling. Journal of bacteriology, 2005. 187(24): p. 8350-8360.
Rutherford, S.T. and B.L. Bassler, Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harbor perspectives in medicine, 2012. 2(11).
Bejerano-Sagie, M. and K.B. Xavier, The role of small RNAs in quorum sensing. Current opinion in microbiology, 2007. 10(2): p. 189-198.
Antunes, L.C.M., R.B. Ferreira, M.M. Buckner, and B.B. Finlay, Quorum sensing in bacterial virulence. Microbiology, 2010. 156(8): p. 2271-2282.
González, J.E. and N.D. Keshavan, Messing with bacterial quorum sensing. Microbiology and Molecular Biology Reviews, 2006. 70(4): p. 859-875.
Mohammed, J., B.M. Abubakar, H. Yusuf, M. d Sulaiman, H. Saidu, A. Idris, and H. Tijani, Bacterial Biofilm: A Major Challenge of Catheterization. J. of Microbiology Res, 2013. 3(6): p. 213-223.
Kaper, J.B. and V. Sperandio, Bacterial cell-to-cell signaling in the gastrointestinal tract. Infection and immunity, 2005. 73(6): p. 3197-3209.
Li, Y.-H. and X. Tian, Quorum sensing and bacterial social interactions in biofilms. Sensors, 2012. 12(3): p. 2519-2538.
Schaefer, A.L., D.L. Val, B.L. Hanzelka, J.E. Cronan Jr, and E. Greenberg, Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. Proceedings of the National Academy of Sciences, 1996. 93(18): p. 9505-9509.
Choi, J., D. Shin, M. Kim, J. Park, S. Lim, and S. Ryu, LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes. PloS one, 2012. 7(5): p. e37059.
Atkinson, S. and P. Williams, Quorum sensing and social networking in the microbial world. Journal of The Royal Society Interface, 2009. 6(40): p. 959-978.
Popham, D.L. and A.M. Stevens, Bacterial Quorum Sensing and Bioluminescence. 2006.
Miller, M.B. and B.L. Bassler, Quorum sensing in bacteria. Annual Reviews in Microbiology, 2001. 55(1): p. 165-199.
Jacobi, C.A., S. Grundler, C.-J. Hsieh, J.S. Frick, P. Adam, G. Lamprecht, I.B. Autenrieth, M. Gregor, and P. Malfertheiner, Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor)–evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model. Gut pathogens, 2012. 4(1): p. 8.
Ni, N., M. Li, J. Wang, and B. Wang, Inhibitors and antagonists of bacterial quorum sensing. Medicinal research reviews, 2009. 29(1): p. 65-124.
Ruzheinikov, S., S. Das, S. Sedelnikova, A. Hartley, S. Foster, M. Horsburgh, A. Cox, C. McCleod, A. Mekhalfia, and G. Blackburn, The 1.2 Å structure of a novel quorum-sensing protein, Bacillus subtilis LuxS. Journal of molecular biology, 2001. 313(1): p. 111-122.
Zhu, J., X. Hu, E. Dizin, and D. Pei, Catalytic mechanism of S-ribosylhomocysteinase (LuxS): direct observation of ketone intermediates by 13C NMR spectroscopy. Journal of the American Chemical Society, 2003. 125(44): p. 13379-13381.
Bassler, B.L., How bacteria talk to each other: regulation of gene expression by quorum sensing. Current opinion in microbiology, 1999. 2(6): p. 582-587.
Agarwal, R., S. Lata, M. Gupta, and P. Singh, Removal of melanoidin present in distillery effluent as a major colorant: a review. Journal of Environmental Biology, 2010. 31(4): p. 521-528.
Khmel, I. and A. Metlitskaya, Quorum sensing regulation of gene expression: A promising target for drugs against bacterial pathogenicity. Molecular Biology, 2006. 40(2): p. 169-182.
Tijani, H.I., I. Abdulrahman, B.M. Abubakar, S. Mohammed, J.N. Mohammed, H. Saidu, and H. Yusuf, Genetic proclivities of two-component modulated aerobiosis (2014). Vol. 2, No. 1, 2014, pp. 1-6
Cámara, M., A. Hardman, P. Williams, and D. Milton, Quorum sensing in Vibrio cholerae. nature genetics, 2002. 32(2): p. 217-218.
Brackman, G., T. Defoirdt, C. Miyamoto, P. Bossier, S. Van Calenbergh, H. Nelis, and T. Coenye, Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC microbiology, 2008. 8(1): p. 149.
Miller, M.B., K. Skorupski, D.H. Lenz, R.K. Taylor, and B.L. Bassler, Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae. Cell, 2002. 110(3): p. 303-314.
Zhu, J., M.B. Miller, R.E. Vance, M. Dziejman, B.L. Bassler, and J.J. Mekalanos, Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proceedings of the National Academy of Sciences, 2002. 99(5): p. 3129-3134.
Tsou, A.M., T. Cai, Z. Liu, J. Zhu, and R.V. Kulkarni, Regulatory targets of quorum sensing in Vibrio cholerae: evidence for two distinct HapR-binding motifs. Nucleic acids research, 2009. 37(8): p. 2747-2756.
Matson, J.S., J.H. Withey, and V.J. DiRita, Regulatory networks controlling Vibrio cholerae virulence gene expression. Infection and immunity, 2007. 75(12): p. 5542-5549.
Ng, W.-L., L. Perez, J. Cong, M.F. Semmelhack, and B.L. Bassler, Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios. PLoS pathogens, 2012. 8(6): p. e1002767.
Joelsson, A., B. Kan, and J. Zhu, Quorum sensing enhances the stress response in Vibrio cholerae. Applied and environmental microbiology, 2007. 73(11): p. 3742-3746.
Faruque, S.M., M.J. Albert, and J.J. Mekalanos, Epidemiology, Genetics, and Ecology of ToxigenicVibrio cholerae. Microbiology and molecular biology reviews, 1998. 62(4): p. 1301-1314.
Brackman, G., S. Celen, U. Hillaert, S. Van Calenbergh, P. Cos, L. Maes, H.J. Nelis, and T. Coenye, Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. PloS one, 2011. 6(1): p. e16084.
Kovacikova, G. and K. Skorupski, Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter. Molecular microbiology, 2002. 46(4): p. 1135-1147.
Ng, W.-L., Y. Wei, L.J. Perez, J. Cong, T. Long, M. Koch, M.F. Semmelhack, N.S. Wingreen, and B.L. Bassler, Probing bacterial transmembrane histidine kinase receptor–ligand interactions with natural and synthetic molecules. Proceedings of the National Academy of Sciences, 2010. 107(12): p. 5575-5580.
Surette, M.G., M.B. Miller, and B.L. Bassler, Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proceedings of the National Academy of Sciences, 1999. 96(4): p. 1639-1644.
Federle, M.J. and B.L. Bassler, Interspecies communication in bacteria. Journal of Clinical Investigation, 2003. 112(9): p. 1291-1299.
von Bodman, S.B., J.M. Willey, and S.P. Diggle, Cell-cell communication in bacteria: united we stand. Journal of bacteriology, 2008. 190(13): p. 4377-4391.
Lenz, D.H., K.C. Mok, B.N. Lilley, R.V. Kulkarni, N.S. Wingreen, and B.L. Bassler, The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae. Cell, 2004. 118(1): p. 69-82.
Rutherford, S.T., J.C. van Kessel, Y. Shao, and B.L. Bassler, AphA and LuxR/HapR reciprocally control quorum sensing in vibrios. Genes & development, 2011. 25(4): p. 397-408.
Hunter, G., F.G. Vasquez, and J. Keener, A mathematical model and quantitative comparison of the small RNA circuit in the Vibrio harveyi and Vibrio cholerae quorum sensing systems. Physical biology, 2013. 10(4): p. 046007.
Hammer, B.K. and B.L. Bassler, Quorum sensing controls biofilm formation in Vibrio cholerae. Molecular microbiology, 2003. 50(1): p. 101-104.
Shen, G., R. Rajan, J. Zhu, C.E. Bell, and D. Pei, Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. Journal of medicinal chemistry, 2006. 49(10): p. 3003-3011.