The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence
Advances in Bioscience and Bioengineering
Volume 2, Issue 1, February 2014, Pages: 1-7
Received: Dec. 31, 2013; Published: Feb. 20, 2014
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Authors
Bashir Mohammed Abubakar, Department of Biological Sciences, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria
Jibrin Ndejiko Mohammed, Department of Microbiology, Ibrahim Badamasi Babangida University Lapai, P.M.B 011, Niger, Nigeria
Abdulrahman Idris, Department of Microbiology, Kaduna State University, P.M.B. 2339, Kaduna, Nigeria
Hamzat Ibiyeye Tijani, Faculty of Bioscience & Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor-bahru, Malaysia
Saidu Haruna, Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
Yusuf Hindatu, Department of Biochemistry, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria
Mohammed Sulaiman, Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
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Abstract
Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.
Keywords
Virulence, Autoinducers, CAI-1, AI-2, LuxO, HapR, Aph A, QS Inhibitors
To cite this article
Bashir Mohammed Abubakar, Jibrin Ndejiko Mohammed, Abdulrahman Idris, Hamzat Ibiyeye Tijani, Saidu Haruna, Yusuf Hindatu, Mohammed Sulaiman, The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence, Advances in Bioscience and Bioengineering. Vol. 2, No. 1, 2014, pp. 1-7. doi: 10.11648/j.abb.20140201.11
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