Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats
Animal and Veterinary Sciences
Volume 1, Issue 2, March 2013, Pages: 12-17
Received: Feb. 5, 2013; Published: Mar. 10, 2013
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Authors
Amira A. Goma, Dept. of Animal Husbandry and wealth development, Faculty of Veterinary Medicine, Alexandria University, Egypt
Usama E. Mahrous, Dept. of Animal Husbandry and wealth development, Faculty of Veterinary Medicine, Damanhour University, Egypt
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Abstract
A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups. In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.
Keywords
Aluminum Toxicity, Rats, Learning Ability, Behavior
To cite this article
Amira A. Goma, Usama E. Mahrous, Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats, Animal and Veterinary Sciences. Vol. 1, No. 2, 2013, pp. 12-17. doi: 10.11648/j.avs.20130102.11
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Walton, J.R. A longitudinal study of rats chr.onically exposed to aluminum at human dietary levels. Neurosci. Lett. 412:29-33 (2007).
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