Chronic Administration of Bauhinia forficata Link Reduced Exploratory Activity Without Affecting Blood Glucose in Healthy Rats
Plant
Volume 5, Issue 5-1, October 2017, Pages: 27-32
Received: Jan. 30, 2017; Accepted: Feb. 6, 2017; Published: Mar. 6, 2017
Views 2214      Downloads 88
Authors
Henriette Gellert Moranza, Department of Animal Morphology and Physiology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University, Jaboticabal, SP, Brazil
Laerte Scanavaca-Júnior, Brazilian Agricultural Research Corporation - EMBRAPA Environment, Jaguariúna, SP, Brazil
Maria Isabel Mataqueiro, Department of Animal Morphology and Physiology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University, Jaboticabal, SP, Brazil
Antonio de Queiroz-Neto, Department of Animal Morphology and Physiology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University, Jaboticabal, SP, Brazil
Guilherme de Camargo Ferraz, Department of Animal Morphology and Physiology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University, Jaboticabal, SP, Brazil
Article Tools
Follow on us
Abstract
This study provides information about the effect of chronic ingestion of a decoction of Bauhinia forficata on the behavior of rats. The aim of this study was to investigate the exploratory activity, anxiety level, and blood glucose of healthy rats submitted to prolonged treatment with a decoction of B.forficata. Twenty male rats, aged two months and weighing approximately 145g were randomly distributed into two groups. The Bauhinia group freely ingested a decoction of B.forficata for 4 weeks, while the control group received water. Body weight, food and fluid intake, and glycemic index were quantified. The open field (OF) and elevated plus maze (EPM) tests were applied at the end of the experiment. Data were analyzed by Student’s t test for unpaired samples, with a significance level of P<0.05. The results of the EPM test were analyzed by the Wilcoxon Signed Rank Test and blood glucose by the Bonferroni test. There were no significant differences in body weight, food intake or glycemic index between the Bauhinia and control groups. Net liquid intake was higher in the Bauhinia group. EPM results did not differ between groups, but in the OF test, the frequencies of rearing and locomotion were lower and immobility time was increased for rats in the Bauhinia group. In conclusion, B.forficata reduced exploratory activity and did not alter blood glucose in healthy rats.
Keywords
Behavior, Exploratory Activity, Ethnopharmacology
To cite this article
Henriette Gellert Moranza, Laerte Scanavaca-Júnior, Maria Isabel Mataqueiro, Antonio de Queiroz-Neto, Guilherme de Camargo Ferraz, Chronic Administration of Bauhinia forficata Link Reduced Exploratory Activity Without Affecting Blood Glucose in Healthy Rats, Plant. Special Issue: Phytotherapy. Vol. 5, No. 5-1, 2017, pp. 27-32. doi: 10.11648/j.plant.s.2017050501.14
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
G. M. Costa-Silva, H. Silva, M. L. F. Cavalcanti, P. Martins, "Autecology of Bauhinia forficata L.: threatened species of extinction in the Caatinga ecosystem", Journal of Biology and Earth Sciences, vol.3, pp.1-15, 2003.
[2]
M. I. Silva, C. T. Melo, L. F. Vasconcelos, A. M. Carvalho, F. C. Sousa, "Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature", Braz Journal Pharmacognosy, vol. 22, pp. 193-207, Jan-Feb 2012.
[3]
G. T. Volpato, D. C. Damasceno, M. V. C. Rudge, C. R. Padovani, I. D. M. P. Calderon, "Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats", J Ethnopharmacol, vol.116, pp.131-37, Feb 2008.
[4]
I. S. Lopes, J. E. R. Silva, I. A. Machado, C. E. M. R. Silva, M. G. Marinho, J. A. F. Rangel, "Lifting of medicinal plants used in the city of Itapetim, Pernambuco, Brazil", Journal of Biology and Drugstore, vol. 7, pp. 115-21, 2012.
[5]
N. Jatav, A. Ganeshpurkar, N. Gupta, C. Ayachi, R. Ramhariya, D. Bansal, N. Dubey, "Nootropic potential of Bauhinia variegata: A systematic study on murine model", Archives of Medicine and Health Sciences, vol. 2, pp. 29-35, July-Dec 2014.
[6]
F. J. B. D. Santos, S. G. D. Lima, G. S. Cerqueira, A. M. D. G. L. Citó, A. A. D. C. Cavalcante, T. H. C. Marques, R. M. D. Freitas, "Chemical composition and anxiolytic-like effects of the Bauhinia platypetala" ,Braz Journal of Pharmacognosy, vol. 22, pp. 507-16, May-June 2012.
[7]
E. M. Cavalcanti, C. Bonafé, M. G. Silva, M. Gerenutti, "Properties of Bauhinia forficata Link in rats: behavioral evaluations", Pharmacologyonline, vol.2, pp.205-11, Agust 2011.
[8]
N. M. Khalil, M. T. Pepato, I. L. Brunetti, "Free radicals cavenging profile and myeloperoxidase in hibition of extracts from antidiabetic plants: Bauhinia forficata and Cissus sicyoides", Biological research, vol. 41, pp. 165-71, 2008.
[9]
S. M. Vasconcelos, D. S. Macedo, C. T. V Melo, A. P. Monteiro, G. Cunha, F. C. F. Sousa, E. R. Silveira, "Central activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice", J Pharm Pharmacol, vol.56, pp. 389-93, March 2004.
[10]
V. G. Mota, F. L. Carvalho, L. C. S. L. Morais, J. Bhattacharyya, R. N. Almeida, J. L. Alencar, "Antinociceptive activity of the chloroform fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in mice", J Biomed Biotechnol, vol. 2011, pp. 1-10, 2011.
[11]
R. Estrada-Reyes, D. Ubaldo-Suárez, A. G. Araujo-Escalona, "Los flavonoides y el Sistema Nervioso Central", Salud mental, vol.35, pp.375-84, Sept-Oct 2012.
[12]
M. S. Davey, C. Atlee, S. R. S. Ashok Bharathi, M. Farook, "Antianxiety effect of methanolic extract of Bauhinia racemosa (lamk) stems bark in mice", IJPBS, vol.2, pp.217-24, April-June 2011.
[13]
M. T. Pepato, A. M. Baviera, R. C. Vendramini, I. L. Brunetti, "Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats", BMC, vol.4, pp.1, June 2004.
[14]
M. T. Pepato, E. H. Keller, A. M. Baviera , I. C. Kettelhut, R. C. Vendramini, I. L. Brunetti, "Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats", J Ethnopharmacol, vol. 81, pp.191-97, July 2002.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186