Phytochemical Evaluation, Anti-obesity and Antihyperlipidemic Effects of Combined Administration of Green Coffee, Cinnamon and Ginger
Volume 5, Issue 5, September 2017, Pages: 80-84
Received: Oct. 8, 2017; Accepted: Oct. 18, 2017; Published: Nov. 8, 2017
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Gehan Fawzy Abdel Raoof, Pharmacognosy Department, National Research Centre, Giza, Egypt
Khaled Younes Mohamed, Internal Medicine Department, National Research Centre, Giza, Egypt
Hala Mahmoud Mohammed, Food Industry Department, Faculty of Agriculture, Cairo University, Cairo, Egypt
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This study aims to evaluate anti-obesity and antihyperlipidemic effects of individual and combined administration of ginger, cinnamon and green coffee on the hyperlipidimic rats. It is the first report dealing with the effects of the combined administration of these three plants as anti-obesity and antihyperlipidemic agents. Sprague-Dawley rats were used, where they divided into 6 groups (7 rats each). Group 1 was kept as a normal control, while the other groups fed on high-fat diet to induce obesity and hyperlipidemia for 4 weeks. Group 2 positive control that was kept obese, while other groups were orally given individual and combined powders of ginger, cinnamon and green coffee in doses 200mg/kg, respectively, for 6 weeks, At the end of the experiment, body weight of rats were recorded. Blood samples were collected for analyses. The results showed that each of individual and combined administration of these plants significantly (P<0.05) decreased the body weight and serum lipids including total lipid, triglyceride and low density lipoprotein when compared with positive control group, while they significantly (P<0.05) increased high density lipoprotein when compared with positive control group. Furthermore, our study showed that the combination of these three plants exhibited better effects than when compared to the individual powder of the plants. In this study we compared the effects of separated and combined administration of cinnamon bark, ginger root, green coffee beans as anti-obesity and antihyperlipidemic agents. The separated and combined administration exhibited significant anti-obesity and antihyperlipidemic effects in obese and hyperlipidemic rats, while the combined administration showed more powerful effects. Previous reports on cinnamon, ginger and green coffee as separately administered were thus confirmed; however, this is, to our knowledge, the first report dealing with the combined form of the three plants. Such combined administration might be useful in developing natural food additives to help address obesity and hyperlipidemia.
Ginger, Cinnamon, Green Coffee, Lipid, Obesity
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Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed, Hala Mahmoud Mohammed, Phytochemical Evaluation, Anti-obesity and Antihyperlipidemic Effects of Combined Administration of Green Coffee, Cinnamon and Ginger, Plant. Vol. 5, No. 5, 2017, pp. 80-84. doi: 10.11648/j.plant.20170505.12
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Power M. L., Schulkin J. Sex differences in fat storage, fat metabolism, and the health risks from obesity: Possible evolutionary origins, Br J Nutr, 99(2008) 931-40.
Hotamisligil G. S., Erbay E. Nutrient sens in gand inflammation in metabolic diseases. Nat Rev Immunol, 8(2008) 923-34.
Devendra D., Liu E., Eisenbarth G. S. Type 1 diabetes: Recent developments. BMJ, 328(2004) 750–754.
Qin B., Nagasaki M., Ren M., Bajotto G., Oshida Y., Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signal in ginrats. Diabetes Res Clin Pract, 62: 1(2003) 39-48.
Moselhy S. S, Ali H. K. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res, 42(2009)93-8.
Azab K. S. h., Mostafa A. H., Ali E. M., Abdel-Aziz M. A. Cinnamon extract ameliorates ionizing gradiation-induced cellular injury in rats. Ecotoxicol Environ Saf, 74(2011) 2324-9.
Vafa M., Mohammadi F., Shidfar F., Sormaghi M. S., HeidariI., Golestan B., et al. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int J Prev Med, 3(2012) 531-6.
Shatwan I. A., Ahmed L. A., Badkook M. M. Effect of barley flour, crude cinnamon, and their combination on glycemia, dyslipidemia, and adipose tissue hormones in type 2 diabeticrats. J Med Food, 16(2013) 656-62.
Lee S. C., Xu W. X., Lin L. Y., Yang J. J., Liu C. T. Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kanehira). J Agric Food Chem, 61(2013) 4905-13.
Abdel-Azeem A. S., Hegazy A. M., Ibrahim K. S., Farrag A. R., El-Sayed E. M. Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. J Diet Suppl, 10(2013) 195-209.
Akhani S. P., Vishwakarma S. L., Goyal R. K. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol, 56(2004) 101-5.
El Rokhel-SM., Yassin N. A, El-Shenawy S. M., Ibrahim B. M. Antihypercholesterolaemic effect of ginger rhizome (Zingibero fficinale) in rats. Inflammopharmacology 1 8(2010) 309-15.
Mahmoud R. H, Elnour W. A. Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats. Eur Rev Med Pharmacol Sci, 17(2013)7 5-83.
Suzuki A., Kagawa D., Ochiai R., Tokimitsu I., Saito I. Green coffee bean extract and its metabolite shaveahy potensive effect in spontaneously hypertensive rats. Hypertens Res, 25(2002) 99–107.
Kozuma K., Tsuchiya S., Kohori J., Hase T., Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 28(2005) 711–8.
Ochiai R., Jokura H., Suzuki A., Tokimitsu I., Ohishi M., Komai N., Rakugi H., Ogihara T. Green coffee bean extract improves human vaso reactivity. Hypertens Res. 27(2004) 731–7.
Shimoda H., Seki E., Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med. 6(2006) 1–9.
Dellalibera O., Lemaire B., Lafay S. Le Svetol, un extrait de cafe´ vert de´ cafe´ ine´, induit une perte depoids et augument le ratio mass emaigre sur masse grasse chez des volontaires en surcharge ponde´ rale. Phytotherapie. 4(2006) 1–4.
Blum J., Lemaire B., Lafay S. Effect of a green decaffeinated coffee extract on glycaemia. Nutra Foods Res. 6(2007) 13–7.
Farah A., De Paulis T., Trugo L. C., Martin P. R. Effect of roasting on the formation of chlorogenic acid lactones in coffee. J Agric Food Chem. 53(2005) 1505–13.
Harbone J. B. Phytochemical methods. London: Chapman and Hall, Ltd.; 1973, pp 49.
Sofowora A. Medicinal plants and Traditional medicine in Africa. Ibadan, Ibadan, Nigeria: Spectrum Books Ltd; 1993, pp 289.
Siger A., Nogala-Kalucka M., Lampart-Szczapa E. The content and antioxidant activity of phenolics compounds in cold-pressed plantoils. J Food Lipids 15(2008) 137–149.
Zhishen J., Mengcheng T., Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem 64(1999) 555–559.
Bhatt B. A., Dube JJ., Dedousis N., Reider J. A., O’Doherty RM. Dietinduced obesity and acute hyperlipidemia reduce Ikappa B alpha levels in rat skeletal muscle in a fiber-type dependent manner. Am J Physiol Regul Integr Comp Physiol 290(2006) R233-40.
Richmond N. Colorimetric determination of total cholesterol and high density lipoprotein cholesterol (HDL). Clin Chem 19(1973) 1350-6.
Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultra centrifuge. Clin Chem 18(1972) 499-502.
Snedecor G. W., Cochran W. G. Statistical Methods. 7th ed. Ames, USA: Iowa State University Press; 1986. pp. 90-9.
Oloyed OI. Chemical profile of unripe pulp of Carica pagaya. Pak J Nutr, 4(2005) 379-381.
Van Acker S. A., Van Den Berg D. J., Tromp MN., Griffioen DH., Van Bennekom WP., Vander Vijgh WJ. Structural aspects of antioxidant activity of flavanoids. Free Radical Bio Med 20(3), (1996) 331-342.
Hertog M. L., Feskens E. J., Hollman PH., Katan MB., Kromhout D. Dietary antioxidants flavonoids and the risk of coronary heart disease: the zutphen elderly study. Lancet, 342(1993) 1007-1011.
Mostafa AS., Hamed YS. Some pharmacological effects of cinnamon and ginger herbs in obese diabeticrats. J Intercult Ethnopharmacol, 3(4) (2014) 144-149.
Salah M., and Reham A. Effect of Combined Administration of Ginger and Cinnamon on High Fat Diet induced Hyperlipidemia in Rats. J. Pharm Chem Biol Sci, 3(4) (2016) 561-572.
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