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Treatment of Cognitive Impairment Using a Computer Program in Patients with Depression in Remission
American Journal of Applied Psychology
Volume 7, Issue 2, March 2018, Pages: 29-36
Received: Mar. 17, 2018; Accepted: Apr. 8, 2018; Published: May 11, 2018
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Yépez Norma, Psychiatry and Mental Health Department, Faculty of Medicine, National Autonomous University of Mexico, Mexico, Mexico
Cortés Jacqueline, Psychiatry and Mental Health Department, Faculty of Medicine, National Autonomous University of Mexico, Mexico, Mexico
Álvarez Luz María, Psychiatry and Mental Health Department, Faculty of Medicine, National Autonomous University of Mexico, Mexico, Mexico
Cortés-Sotres José Francisco, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, Mexico, Mexico
Heinze Gerhard, Postgraduate Studies Division, National Autonomous University of Mexico, Mexico, Mexico
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The patient with depressive disorder presents a cognitive impairment which does not disappear despite the fact that the depression is considered to be in remission. This study aims to assess the impact of training in the improvement of cognitive functions of patients with remitted depression (RD). Captain’s Log Computerized Cognitive-Training Program (CLCT) was used as a cognitive trainer in a group of patients with RD and with Selective serotonin reuptake inhibitors (SSRI) as treatment; another group with RD was treated uniquely with SSRI. The treatment intervention’s impact was evaluated using the Hamilton Rating Scales for Anxiety and Depression, the Wechsler Adult Intelligence Scale (WAIS-III), and the Integrated Program of Neuropsychological Examination-Revised Barcelona Test. CLCT was used in college students with RD, twice a week, for six months. Patients from both groups decreased depressive and anxious symptoms, however, patients who received CLCT substantially increased their intellectual performance; changes in the psychometric analysis of the Barcelona Test were consistent with the ones presented in WAIS-III. CLCT application is associated with an improvement of cognitive functions in patients with RD.
Depression, Remission, Cognitive Functions, Cognitive Stimulation, College Students
To cite this article
Yépez Norma, Cortés Jacqueline, Álvarez Luz María, Cortés-Sotres José Francisco, Heinze Gerhard, Treatment of Cognitive Impairment Using a Computer Program in Patients with Depression in Remission, American Journal of Applied Psychology. Vol. 7, No. 2, 2018, pp. 29-36. doi: 10.11648/j.ajap.20180702.11
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sandford, J., Captain’s Log Cognitive Trainer, Braintrain, USA. 2011.
World Health Organization, Depression and Other Common Mental Disorders. 2005.
Osornio, C., Palomino, G. “Depresión en estudiantes universitarios.” Archivos en Medicina Familiar, 11 (1): 1-2, 2009.
Heinze G., Villamil V. & Cortés J. F. “Relapse and recurrence of depressed patients: a retrospective study.” Salud Mental, 25 (1): 3-8., 2002.
Manelic R. & Ortega-Soto H. “La depresión en los estudiantes universitarios de la Escuela Nacional de Estudios Profesionales Aragón.” Salud Mental, 18 (2): 31-34, 2005.
Olmedo-Buenrostro, B., Torres-Hernández, J., Velasco-Rodríguez, R., Mora-Brambila, A. y Blas-Vargas, L. “Prevalencia y severidad de depresión en estudiantes de enfermería de la Universidad de Colima.” Revista de Enfermería Del IMSS, 14 (1): 17-22, 2006.
Heiligenstein, E., Guenther, G., Hsu, K. & Herman, K. “Depression and academic impairment in college students.” Journal of American College Health, 49 (6): 299-305, 1996.
Field T, Diego, M & Sanders, C. “Adolescent depression and risk factors.” Adolescence, 36 (143): 491-498, 2001.
López B, González-de Cossío O, Ávila M, Teos A. “Condicionantes epidemiológicos de salud y su relación con rendimiento escolar en el primer año de la carrera de medicina, Estudio de dos generaciones.” Gac Méd Méx, 146 (2):81-90, 2009.
Furr R, Westefeld S, McConnell N, Jenkins M. “Suicide and depression among college students: A decade later.” Professional Psychology Research Practice, 32: 97-100, 2001.
Austin, M., Mitchel, P., & Goodwin, G. “Cognitive deficits in depression: possible implications for functional neuropathology.” British Journal of Psychiatry, 178:200-2006, 2001.
Paelecke- Habermann, Y., Pohl, J. & Leplow, B. “Attention and executive functions in remitted major depression patients.” Journal of Affective Disorders, 89: 125-135, 2005.
Sobin, C., Sackeim, H., Mann, J. & Thase, M.” Psychomotor symptoms of depression.” American Journal of Psychiatry: 154, 4-17, 1998.
Weiland- Fiedler, P., Erickson, K., Waldeck, T., Luckenbaugh, A., Pike, D., Bonne, E. “An evidence for continuing neuropsychological impairments in depression.” Journal of Affective Disorders, 82: 253-258, 2004.
Christopher, G. & MacDonald, J. “The impact of clinical depression on working memory”, Cognitive Neuropsychiatry, 10 (5): 379-399, 2005.
Mintz J, Mintz L, Arruda M, Hwang S. “Treatments of depression and the functional capacity to work.” Arch Gen Psychiatry. Oct; 49 (10):761–768, 1992.
Rapport, M., Denney, C., Chung, K & Hustace, K. “Internalizing behavior problems and scholastic achievement in children: cognitive and behavioral pathways as mediators of outcome.” Journal of Clinical Child Psychology, 30 (4): 536-551, 2001.
De la Peña, F., Estrada, A., Almeida, L. & Paez, F. “Prevalencia de los trastornos depresivos y su relación con el bajo aprovechamiento escolar en estudiantes de secundaria.” Salud Mental, 22 (4): 9-13, 1999.
Keller, M. “Past, present and future directions for defining optimal treatment outcome in depression: remission and beyond.” JAMA. 289 (31): 52-60, 2003.
Zimmerman M., Posternak M., Chelminski I. “Heterogeneity among depressed outpatients considered to be in remission.” Compr Psychiatry, 48:113-7, 2007.
Slate, S. Meyer, T. Burns, W. Montgomery, D. “Computerized cognitive training for severely emotionally disturbed children with ADHD.” Behavior modification, July; 22 (3): 417-437, 1998.
Kotwal, D., Burns, W. & Montgomery, D. “Computer-assisted cognitive training for ADHD: A case study.” Behavior Modification, 20 (1): 85-96, 1996.
Sartory, G., Zorn, C., Groetzinger, G. y Windgassen, K. “Computerized Cognitive remediation improves verbal learning and processing speed in schizophrenia.” Schizophrenia Research. 75: 219-223, 2005.
McGurk, S., Twamley, E., Sitzer, D., McHugo, G., Mueser, K. “A Meta-Analysis of Cognitive Remediation in Schizophrenia.” Am J. Psychiatry. Dec; 164 (12): 1791-1802, 2007.
Cortese, S. Ferrin, M., Brandeis, D., Buitelaar, J., Daley, D., Dittmann, R., Holtman, M., Santosh, P., Stevenson, A., Sonuga-Barke, E. “Cognitive Training for Attention Deficit Hyperactivity Disorder: Meta-Analysis of Clinical and Neuropsychological Outcomes from Randomized Controlled Trials.” J Am Acad Child Adolesc Psychiatry, 54 (3): 164-174, 2015.
Preiss, M., Shatil, E., Cermákova, R., Cimeranova, D. & Ram L. “Personalized Cognitive training in Unipolar and bipolar disorder: a study of cognitive functioning.” Frontiers in Human Neuroscience. (7) (Article 108): 1-10, 2013.
Bellucci, D. Glaberman, K., Haslam, N. “Computer-assisted cognitive rehabilitation reduces negative symptoms in the severely mentally ill.” Schizophrenia Research, 59: 225-232, February 2003.
Álvarez, L., Cortés, J., Ortiz, S., Estrella, J., Sánchez, J. “Computer program in the treatment for major depression and cognitive impairment in university students.” Computers in Human Behavior, 24: 816-826, 2008.
Álvarez L., Yépez N., Jurado M., Guerrero J., Petra I. “Stimulation of Cognitive Functions in University Students with Obsessive Compulsive Disorder Using Captain’s Log Computerized Cognitive Training Program.” American Journal of Applied Psychology. 7 (1): 1-10, 2018.
Hill, N., Mowzowski, L., Naismith, S., Chadwick, V., Valenzuela, M., Lampit, A. (2017). “Computerized Cognitive Training in Older Adults with Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.” Am J Psychiatry. Apr 1; 174 (4), 2017.
Edwards, J., Xu, H., Clark, D., Guey, L., Ross, L., Unverzagt, F. “Speed of processing training results in lower risk of dementia.” Alzheimer´s & Dementia: Translational Research & Clinical Interventions. 3:603-611, Nov 2017.
Bloom, R., Schnaider-Beeri M, Ravona-Springer R. “Computerized Cognitive Training for Older Diabetic Adults at Risk of Dementia: Study Protocol for a Randomized Controlled Trial.” Alzheimer’s & Dementia : Translational Research & Clinical Interventions 3.4: 636–650. PMC. Web. Feb. 2018.
Cerasa, A., Gioia, M., Valentino, P., Nistico, R., Chiriaco, C., Pirritano, D., Tomaiolo, F., Magnone, G., Trotta, M., Talarico, T. “Computer-assisted cognitive rehabilitation of attention deficits for multiple sclerosis: a randomized trial with fMRI correates.” Neurorehabil Neural Repair. 27 (4):284–95, 2013.
Bonavita, S., Sacco, R., Della Corte, M., Esposito, S., Sparaco, M., d’Ambrosio, A. “Computer-aided cognitive rehabilitation improves cognitive performances and induces brain functional connectivity changes in relapsing remitting multiple sclerosis patients: an exploratory study.” J Neurol. 262 (1):91–100, 2015.
Haier, R., Karama, S., Leyba, L., Jung, R. “MRI assessment of cortical thickness and functional activity changes in adolescent girls following three months of practice on a visual-spatial task.” BMC Research Notes 2:174, 2009.
Sheline Y, Gado M & Kraemer H. “Untreated Depression and hippocampal volume loss.” American Journal of Psychiatry 160 (8): 1516-1518, 2003.
Chiaravalloti, N. Genova, H., DeLuca, J. “Cognitive Rehabilitation in Multiple Sclerosis: The Role of Plasticity.” Front Neorol. 6:67, 2015.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-5. American Pychiatric Publishing. Washington, London, 2013.
Heinze G., Villamil V. & Cortés, J. F. “Relapse and recurrence of depressed patients: a retrospective study.” Salud Mental, 25 (1): 3-8, 2002.
Ramos-Brieva, J. C., “A new validation of the Hamilton Rating Scale for Depression”. J Psychiatr Res (22): 21-28, 1988.
Zimerman, M. Martínez, J., Attiullau, N., Friedman, M., Toba, C. Boerescu, D. “Why do some depressed outpatients who are in remission according to the Hamilton Depression Rating Scale not consider themselves to be in remission?” J Clin Psychiatry, 73: 790-795, 2012.
Hamilton, M. “Diagnosis and rating of anxiety. In Studies of Anxiety, Lander, M. H.” Brit Journal Psychiat Spec Pub. 3:76-79, 1969.
Wechsler D. Escala Wechsler de Inteligencia para Adultos. WAIS-III. Manual Moderno. 218, México, 2018.
Peña-Casanova, J. Test Barcelona-R: Teoría e interpretación. Masson Segunda Edición. Barcelona, 2007.
Villa, R. M. Programa Integrado de exploración Neuropsicológica. Test Barcelona R. Versión abreviada. Adaptación para la Aplicación en México. Facultad de Estudios Superiores (FES), Zaragoza. Universidad Nacional Autónoma de México (UNAM), 1999.
Cohen, J. Statistical Power Analysis for the Behavioral Sciences, Hillsdale, 2nd Edition, N. J.: Lawrence Erlbaum, 1988.
Jaeggi, S., Buschkuehl, M., Jonides, J., Perrig, W. “Improving fluid intelligence with training on working memory.” Proc Natl Acad Sci USA, 105 (19), May 2008.
Eriksson, S., Perfilieva, E., Bjöjk- Eriksson, T., Alborn, A., Nordborg, C., Peterson, A. “Neurogenesis in the adult human hippocampus.” Nature Medicine, 4 (11), 1313 1317, 1998.
Prado, R. & Bermúdez, F. Memoria: dónde reside y cómo se forma, Trillas, México, 2001, pp.157.
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