Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review
Science Journal of Clinical Medicine
Volume 9, Issue 1, March 2020, Pages: 1-6
Received: Dec. 24, 2019;
Accepted: Jan. 2, 2020;
Published: Jan. 10, 2020
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Sameer Sharma, Department of Biotechnology, Indian Academy Degree College-Autonomous, Bangalore, India
Rajan Chourasiya, Department of Biotechnology, Indian Academy Degree College-Autonomous, Bangalore, India
Shahna T, Department of Biotechnology, Indian Academy Degree College-Autonomous, Bangalore, India
Gaddam Roopa Shivani, Department of Biotechnology, Indian Academy Degree College-Autonomous, Bangalore, India
Anaerobic glycolysis advertise the production of energy under hypoxic condition (absence of oxygen), while in aerobic glycolysis, the Warburg effect gives a momentous benefit through remodeling carbohydrates seeds from production of energy to biochemical pathways. On the other side, high degree of lactate have been cooperated with feeble outcome in human tumors as well as glycolytic switch is correlated with high rate of glucose uptake and lactate production. Although lactic acid was primarily remind as indicator of the glycolytic process in which many mechanisms initiates from the study of normal tissue physiology and transported to the tumor indicating lactic acid in essence lactate anion and protons, straightly contributes to tumor growth and development. MCT1 & MCT4 monocarboxylate transporters have been justified as well-known facilitators of lactate exchanges between various cancer cells with many metabolic behaviors. In this review, we summarize the current knowledge on the role of lactic acidosis and metastasis, lactate shuttles and lactate signaling molecules.
Gaddam Roopa Shivani,
Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review, Science Journal of Clinical Medicine.
Vol. 9, No. 1,
2020, pp. 1-6.
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