Please enter verification code
Special Issues
Study the Relation Between Acetylcholinesterase and Obesity in University Students
International Journal of Nutrition and Food Sciences
Volume 8, Issue 3, May 2019, Pages: 46-51
Received: Jul. 31, 2019; Accepted: Aug. 20, 2019; Published: Sep. 3, 2019
Views 794      Downloads 294
Asmaa Fathi Hamouda, Department of Biochemistry, Faculty of Science, University of Alexandria, Alexandria, Egypt; Medical Laboratory Technology Department, Faculty of Applied Health Sciences, Jazan University, Jazan, Kingdom of Saudi Arabi; Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Ibrahim Abdu Khardali, Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Ibraheem Mohammed Attafi, Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Magbool Essa Oraiby, Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Mohammad Ahmad Attafi, Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Ali Mousa Sulaiman Muyidi, Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Jazan, Kingdom of Saudi Arabia
Hassan Abdu Ahmed Dohali, Ministry of Health, Abu-Arish General Hospital Jazan, Jazan, Kingdom of Saudi Arabia
Article Tools
Follow on us
Obesity is described as an asymmetrical body weight for height with an extreme growth of adipose tissue that is usually with the highest risk of disordered lipid profile. Obesity is caused by a sequence of excessive food intake, absence of physical motion, and hereditary predisposition. A few instances are caused primarily by genes, endocrine dysfunctions, medicines, or mental confusion. BMI gives a simple numeric test of obesity. BMIs below 20.0kg/m2 and above 25.0kg/m2 has been connected with significant various health problems and most of mortality incidence causes. The recent investigations indicate a relationship between obesity, acetylcholinesterase (AChE) activities, and short-term weight loss in obese. A total of 39 female students, 18-35 years old, involved in this investigation to evaluate the relationship between body mass index (BMI), blood lipid, and AChE in female’s university students. The present study reveals a strong correlation between BMI and lipid profile. As well, there is a weak negative relation between AChE and BMI in current work. But, All results of AChE in the present results within the reference range. Further long-term studies with a higher number and different types of sexes will be needed to validate and complete evaluate the specific relation between obesity and AChE.
Obesity, Lipid Profile, BMI, Acetylcholinesterase
To cite this article
Asmaa Fathi Hamouda, Ibrahim Abdu Khardali, Ibraheem Mohammed Attafi, Magbool Essa Oraiby, Mohammad Ahmad Attafi, Ali Mousa Sulaiman Muyidi, Hassan Abdu Ahmed Dohali, Study the Relation Between Acetylcholinesterase and Obesity in University Students, International Journal of Nutrition and Food Sciences. Vol. 8, No. 3, 2019, pp. 46-51. doi: 10.11648/j.ijnfs.20190803.11
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pêgo-Fernandes PM, Bibas BJ, Deboni M (2011). Obesity: the greatest epidemic of the 21st century? Sao Paulo Med J; 129 (5): 283-4.
Hamouda FH (2016). The Association between Lifestyle, Anthropometric Measurements, and Obesity in University Students. Journal of Pharmacy and Pharmacology 4, 119-127.
Abdul Rahman Al-Ajlan (2011). Lipid Profile in Relation to Anthropometric Measurements among College Male Students in Riyadh, Saudi Arabia: A Cross-Sectional Study. journal of Biomedical science. (Int J Biomed Sci; 7 (2): 112-119).
Tvarijonaviciute Al, Ceron JJ, Tecles F (2013). Acetylcholinesterase and butyrylcholinesterase activities in obese Beagle dogs before and after weight loss. Vet Clin Pathol; 42 (2): 207-11.
Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC (2005). The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol; 5: 23.
Debette S, Seshadri S, Beiser A, et al (2011). Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology; 77 (5): 461-8.
Enzinger C, Fazekas F, Matthews PM, et al (2005). Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology; 64 (10): 1704-11.
Pannacciulli N, Del Parigi A, Chen K, Le DS, Reiman EM, Tataranni PA (2006). Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage; 31 (4): 1419-25.
Bolzenius JD, Laidlaw DH, Cabeen RP, et al (2013). Impact of body mass index on neuronal fiber bundle lengths among healthy older adults. Brain Imaging Behav (3): 300-6.
Stanek KM, Strain G, Devlin M, et al (2013). Body mass index and neurocognitive functioning across the adult lifespan. Neuropsychology; 27 (2): 141-51.
Ford ES, Mokdad AH, Giles WH (2003). Trends in waist circumference among U.S. adults. Obes Res; 11 (10): 1223-31.
Whitmer RA, Gustafson DR, Barrett-Connor E, Haan MN, Gunderson EP, Yaffe K (2008). Central obesity and increased risk of dementia more than three decades later. Neurology; 71 (14): 1057-64.
Jagust W, Harvey D, Mungas D, Haan M (2005). Central obesity and the aging brain. Arch Neurol; 62 (10): 1545-8.
Toolabi K, Arefanian S, Golzarand M, Arefanian H (2011). Effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) on weight loss and biomarker parameters in morbidly obese patients: a 12-month follow-up. Obes Surg; 21: 1834–42.
Deutsche GKC (1992). Proposal of standard methods for the determination of enzyme catalytic concentrations in serum and plasma at 37C. II Cholinesterase (acylcholine acylhydrolase, EC Eur J Clin Chem Clin Biochem; 30: 163.
Cruz KJ, de Oliveira AR, Morais JB, et al (2017). Role of microRNAs on adipogenesis, chronic low-grade inflammation, and insulin resistance in obesity. Nutrition; 35: 28–35.
Hamouda AF, Abou El Noeman SA (2016). Effects of 6-Month Weight Loss New Program on Anthropometric Measurements and Biological Profile. Journal of Pharmacy and Pharmacology (4) 23-38.
Hamouda AF, Abou El Noeman SA, Khardalic IA, et al (2018). Study the Association Between Diet Program on Human Semen, Biological Profile, and Anthropometric Measurements in Obese Men. International Journal of Nutrition and Food Sciences; 7 (1): 24-29.
Shani ST, Shiri SD, Galia B, et al. (2019) Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy (2018). Int J Obes (Lond); 43 (2): 297-305.
Tentolouris N, Liatis S, Katsilambros N (2006). Sympathetic system activity in obesity and metabolic syndrome. Ann N Y Acad Sci; 1083: 129–52.
Poirier P, Hernandez TL, Weil KM, Shepard TJ, Eckel RH (2003). Impact of diet-induced weight loss on the cardiac autonomic nervous system in severe obesity. Obes Res; 11: 1040–7.
Karason K, Molgaard H, Wikstrand J, Sjostrom L (1999). Heart rate variability in obesity and the effect of weight loss. Am J Cardiol; 83: 1242–7.
Ofek K, Soreq H (2013). Cholinergic involvement and manipulation approaches in multiple system disorders. Chem-Biol Interact; 203: 113–9.
Shenhar-Tsarfaty S, Berliner S, Bornstein NM, Soreq H (2014). Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. J Mol Neurosci; 53: 298–305.
Myers MG, Olson DP (2012). Central nervous system control of metabolism. Nature; 491: 357–63.
Thorp AA, Schlaich MP (2015). Relevance of sympathetic nervous system activation in obesity and metabolic syndrome. J Diabetes Res: 341583.
Metz CN, Tracey KJ (2005). It takes nerve to dampen inflammation. Nat Immunol; 6: 756–57.
Borovikova LV, et al (2000). Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature; 405: 458–62.
Soreq H, Seidman S (2001). Acetylcholinesterase--new roles for an old actor. Nat Rev Neurosci; 2: 294–302.
Das UN (2007). Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Med Sci Monit; 13: Ra214–21.
Mirjana BO, Danijela ZK, Tamara DL, et al (2013). Acetylcholinesterase Inhibitors: Pharmacology and Toxicology Current Neuropharmacology, 11, 315-335 315.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186