Monostyrene Intake in Albino Rats: Accumulation in Organs and Effects on Growth Performance and Oxidative Stress
International Journal of Nutrition and Food Sciences
Volume 5, Issue 1, January 2016, Pages: 72-79
Received: Jan. 25, 2016; Accepted: Feb. 4, 2016; Published: Feb. 26, 2016
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Mohamed G. El-Ziney, Department of Dairy Science and Technology, Faculty of Agriculture - Al Shatby, Alexandria University, Alexandria, Egypt
Hana BaAbdoulah, Department of Nutrition, King Saud University, Riyadh, Saudi Arabia
Manal S. Tawfik, Department of Food Science and Technology, Faculty of Agriculture - Al Shatby, Alexandria University, Alexandria, Egypt
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Monostyrene (MS) residuals are daily migrating from different polystyrene shaping containers to our foods. In the present study, the distribution, accumulation and clearness rate of MS in different organs were done by one oral gavage of sub-lethal dose of 500 mg/kg bwt in male albino rates. Following MS in kidney, liver and brain indicated that the highest concentration peak was reached after 3 hr. Meanwhile, the maximum and minimum levels were detected in kidney (190.6 µg/100g) and brain (12.8 µg/100g), respectively. After 3 hr of styrene administration, the same decline rate was observed in the three organs. The clearness and metabolites rates of MS after 7 hr of administration were 93%, 76.9% and 71.1% in kidney, liver and brain, respectively. Further, this study investigated the effects of different MS at doses (0.1, 0.3 and 1.0 mg/kg) on growth performance parameters included weight gain (WG), relative liver weight, food efficiency ratio (FER), protein efficiency ratio (PER) and on oxidative stress biomarker; malondialdehyde (MDA) in the plasma of male and female albino rats after 12 weeks of feeding. All tested MS concentrations showed significant effects (P >0.05) on WG, FER and PER of either male or female rats compared to the control group. All these indices were more pronounced in both male and female that administrated MS at dose of 1.0 mg MS/kg bwt. Only in female, relative liver weight was affected significantly at doses of 0.3 and 1.0 mg/kg bwt of MS. Significant differences (P >0.05) were found among the experimental groups in malondialdehyde concentration in plasma of male and female rats; but not in nonlinear behavior. MDA concentration increased significantly (P >0.05) in female plasma compared to male at all tested doses. Styrene concentration in male liver after three months at oral administration of 1 mg/kg was 1.72 µg/100g. It is concluded that MS at tested levels had affected growth performance parameters and led to increase oxidative stress which could have significant health risks. Kidney is the main organ responsible for MS elimination. More precaution should be addressed to food packaging industry to control and monitor MS release from PS food contact materials.
Monostyrene, Dairy Polystyrene Packages, Oxidative Stress, Malonaldialdehyde, Weight Gain, Food Efficiency, Styrene Distribution in Organs
To cite this article
Mohamed G. El-Ziney, Hana BaAbdoulah, Manal S. Tawfik, Monostyrene Intake in Albino Rats: Accumulation in Organs and Effects on Growth Performance and Oxidative Stress, International Journal of Nutrition and Food Sciences. Vol. 5, No. 1, 2016, pp. 72-79. doi: 10.11648/j.ijnfs.20160501.21
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